A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
While filing for a divorce, beautiful ex-stripper Roslyn Taber ends up meeting aging cowboy-turned-gambler Gay Langland and former World War II aviator Guido Racanelli. The two men instantly become infatuated with Roslyn and, on a whim, the three decide to move into Guido's half-finished desert home together. When grizzled ex-rodeo rider Perce Howland arrives, the unlikely foursome strike up a business capturing wild horses.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
Lt. Col. Kirby Yorke is posted on the Texas frontier to defend settlers against depredations of marauding Apaches. Col. Yorke is under considerable stress by a serious shortage of troops of his command. Tension is added when Yorke's son (whom he hasn't seen in fifteen years), Trooper Jeff Yorke, is one of 18 recruits sent to the regiment.
An outlaw calling himself Passin' Through halts his "evil" ways long enough to help out some children in difficulty.
Stan and Ollie try to deliver the deed to a valuable gold mine to the daughter of a dead prospector. Unfortunately, the daughter's evil guardian is determined to have the gold mine for himself and his saloon-singer wife.
John Breen (John Wayne), a Kentucky militiaman falls in love with French exile Fleurette De Marchand (Vera Ralston). He discovers a plot to steal the land that Fleurette's exiles plan to settle on and aims to foil it.
On the run after committing murder, an accountant encounters a strange Native American man who prepares him for his journey into the spiritual world.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
Newly appointed sheriff Pat Garrett is pleased when his old friend Doc Holliday arrives in Lincoln, New Mexico on the stage. Doc is trailing his stolen horse, and it is discovered in the possession of Billy the Kid. In a surprising turnaround, Billy and Doc become friends. This causes the friendship between Doc and Pat to cool. The odd relationship between Doc and Billy grows stranger when Doc hides Billy at his girl Rio's place after Billy is shot.
Three brothers stop off for a night in the town of Tombstone. The next morning they find one of their brothers dead and their cattle stolen. They decide to take revenge on the culprits.
Following the Civil War, headstrong rancher Thomas Dunson decides to lead a perilous cattle drive from Texas to Missouri. During the exhausting journey, his persistence becomes tyrannical in the eyes of Matthew Garth, his adopted son and protégé.
Will Kane, the sheriff of a small town in New Mexico, learns a notorious outlaw he put in jail has been freed, and will be arriving on the noon train. Knowing the outlaw and his gang are coming to kill him, Kane is determined to stand his ground, so he attempts to gather a posse from among the local townspeople.
Two peanut vendors at a rodeo show get in trouble with their boss and hide out on a railroad train heading west. They get jobs as cowboys on a dude ranch, despite the fact that neither of them knows anything about cowboys, horses, or anything else.
Chester Wooley and Duke Egan are travelling salesmen who make a stopover in Wagon Gap, Montana while enroute to California. During the stopover, a notorious criminal is murdered, and the two are charged with the crime.
When the government opens up the Oklahoma territory for settlement, restless Yancey Cravat claims a plot of the free land for himself and moves his family there from Wichita. A newspaperman, lawyer, and just about everything else, Cravat soon becomes a leading citizen of the boom town of Osage. Once the town is established, however, he begins to feel confined once again, and heads for the Cherokee Strip, leaving his family behind. During this and other absences, his wife Sabra must learn to take care of herself and soon becomes prominent in her own right.
A fiercely independent cowboy arranges to have himself locked up in jail in order to then escape with an old friend who has been sentenced to the penitentiary.
Family relationships of a New Mexico family are just one part of this silent cowboy western about a war veteran who finds a goldmine. He wants to earn enough money to take care of his young son, but crooked officials swindle him out of the mine, and then his son is killed. He swears vengeance and joins up with Mexican bandit, "Pancho Zapilla", who intends to destroy his whole town.
Tom Destry, son of a legendary frontier peacekeeper, doesn’t believe in gunplay. Thus he becomes the object of widespread ridicule when he rides into the wide-open town of Bottleneck, the personal fiefdom of the crooked Kent.
After the Civil War, Confederate soldiers Clint and Vance Reno steal a Union payroll, leading to conflict when the younger marries the woman his older brother loves.