Retired wealthy sea captain Jim McKay arrives in the Old West, where he becomes embroiled in a feud between his future father-in-law, Major Terrill, and the rough and lawless Hannasseys over a valuable patch of land.
As the west rapidly becomes civilized, a pair of outlaws in 1890s Wyoming find themselves pursued by a posse and decide to flee to South America in hopes of evading the law.
A cowboy who was trying to return the loot from a robbery finds hmself suspected of the crime.
Outlaws of the Pandhandle was the last of Charles Starrett's "formula" westerns for Columbia: hereafter, Starrett would be seen only in the guise of frontier medico Steven Monroe or masked do-gooder The Durango Kid. For the moment, however, the star is cast as Jim Endicott, bound and determined to put an end to the underhanded activities of gin-mill operator Faro Jack Vaughn (Norman Willis). The villain's strategy is to get the local cowpunchers tanked up on rotgut that they'll prove to be easy pickings for a gang of rustlers-and will be unable to complete work on a railroad spur which will bypass the outlaws' hideaway.
A town is cleared of crime when a group of cowboys under the direction of Hayden battles an outlaw gang. They also manage to restore the reputation of a friend wrongly accused of murder.
A posse discovers a trio of men they suspect of murder and cow theft and are split between handing them over to the law or lynching them on the spot.
After the train station clerk is assaulted and left bound and gagged, then the departing train and its passengers robbed, a posse goes in hot pursuit of the fleeing bandits.
Rancher Clay Hardin arrives in San Antonio to search for and capture Roy Stuart, notorious leader of a gang of cattle rustlers. The vicious outlaw is indeed in the Texan town, intent on winning the affections of a beautiful chanteuse named Jeanne Starr. When the lovely lady meets and falls in love with the charismatic Hardin, the stakes for both men become higher.
Captain Porter's scheme is to buy livestock and then have his men show up later to kill the buyer and retrieve the money. When his men kill the next victim, he frames the Arizonian for the murder. The Arizonian escapes the law and joins up with the outlaw Vasquez. Knowing Porter's scheme, he plans to trap him by using Vasquez as the next buyer.
Marshall Dan Mitchell, who is the law in Abilene, has the job of keeping peace between two groups. For a long time, the town had been divided, with the cattlemen and cowboys having one end of town to themselves, while townspeople occupied the other end. Mitchell liked it this way, it made things easier for him, and kept problems from arising between the two factions. However…
A sheriff tracking a gang of rustlers discovers that one of them is the brother of his fiance.
Bandits lead by Matt the Mute enter a bar and kill multiple people. Randy Bowers comes to town and is framed by Matt the Mute, who is working with the sheriff (who doesn't know Matt is really a criminal). Randy escapes with the help of the niece of the dead owner of the bar. Bowers ends up running from the sheriff, and ends up in the cave in which the bandits have their hide-out…
Young Travis Coates is left to take care of the family ranch with his mother and younger brother while his father goes off on a cattle drive in the 1860s. When a yellow mongrel comes for an uninvited stay with the family, Travis reluctantly adopts the dog.
A drought is about to end the cattle business. The owner of a canning factory wants to buy all the remaining cattle cheap. He plans to ruin the cattlemen's plans to ship water by train and to seed the clouds for rain. Roy is sent by a packing house to investigate.
Three outlaws on the run discover a dying woman and her baby. They swear to bring the infant to safety across the desert, even at the risk of their own lives.
A noted gunman takes a job on a cattle ranch to stop a band of rustlers.
Lambert, a young man out to make his fortune, is out west trying to sell a gadget that can peel potatoes, open cans, pull out nails and perform other handy tasks. He comes to a cattle ranch and runs into a group of cowboys eating supper. He impresses the cowboys so much that they make him their leader, and it's not long before he's hired by pretty young ranch manager Vesta Philbrook as her aide and bodyguard. "The Duke", as he's now called, falls in love with her and sets out to help her get rid of a gang of vicious cattle rustlers that are constantly raiding her ranch.
When his cattlemen abandon him for the gold fields, rancher Wil Andersen is forced to take on a collection of young boys as his cowboys in order to get his herd to market in time to avoid financial disaster. The boys learn to do a man's job under Andersen's tutelage, however, neither he nor the boys know that a gang of cattle thieves is stalking them.
Following the Civil War, headstrong rancher Thomas Dunson decides to lead a perilous cattle drive from Texas to Missouri. During the exhausting journey, his persistence becomes tyrannical in the eyes of Matthew Garth, his adopted son and protégé.
A former gunslinger is forced to take up arms again when he and his cattle crew are threatened by a corrupt lawman.