William Blake, an accountant turned fugitive, is on the run. During his travels, he meets a Native American man called Nobody, who guides him on a journey to the spiritual world.
While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.
William Munny is a retired, once-ruthless killer turned gentle widower and hog farmer. To help support his two motherless children, he accepts one last bounty-hunter mission to find the men who brutalized a prostitute. Joined by his former partner and a cocky greenhorn, he takes on a corrupt sheriff.
Steve Kinney and his henchman, Mort, are trying to stir up trouble between the local ranchers and farmers, behind a wave of rustling and lawlessness. Mort kills Vic, a Kirby cowhand, and lays the blame on Dan Harper, the leader of the farmers faction. Storekeeper Fuzzy Q. Jones, fearful of losing the outstanding charge-accounts he has on his books, drags his reluctant pal, Billy Carson, into the fray, and the two soon prove Kinney and his henchmen to be behind the valley's troubles.
Bank robber Graham Dorsey spends a few hours with beautiful widow Amanda Starbuck, in which time his gang takes part in a disastrous holdup. Learning of his comrades' demise, Dorsey goes on the lam. Believing her short-term lover was killed by the law, Amanda decides to make the most of having had a liaison with the supposedly deceased desperado by writing a book about him. Much to his confusion, the still-living Dorsey watches as his name becomes legendary.
Before the U.S. Civil War rebel leader Luke Darcy sees himself as leader of a new independent Republic of Kansas but the military governor sends an ex-raider to capture Darcy.
Cole Thornton, a gunfighter for hire, joins forces with an old friend, Sheriff J.P. Harrah. Together with a fighter and a gambler, they help a rancher and his family fight a rival rancher that is trying to steal their water.
Brown fights a swindler and his pal, Hatton, finds a way to help a robbery victim buy back his property.
Outlaws plan a robbery to take place during a championship prizefight in Carson City, Nevada.
Residents of a small frontier town take up arms when vigilantes try to block a railroad right-of-way.
After the train station clerk is assaulted and left bound and gagged, then the departing train and its passengers robbed, a posse goes in hot pursuit of the fleeing bandits.
A former sheriff begins to persecute the gang led by Pedro Ortiz, after his wife is taken away.
Carl Beldon has disappeared and the Trail Blazers have been sent to investigate. Arriving in town, they find that 'Honest John' controls everything. He even prints his own money. He also has a gang and they set out to finish off the heroes.
A peace-loving, part-time sheriff in the small town of Firecreek must take a stand when a gang of vicious outlaws takes over his town.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
In a cantina across the border, Bob Hamlin shoots a man that threatens his friend. He and his pals escape but return that night for the dance as Bob is attracted to Conchita. Running once more from the Rurales, Bob takes Conchita. They escape again only to find themselves pinned down when Buck and his gang of horse thieves attack.
In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.
U.S Marshal Mike Donovan has dark memories of the death of his first love. He keeps peace between the Americans and the natives who had temporarily adopted and taken care of him. The evil actions of a white sorcerer lead him to confront the villain in the Sacred Mountains, and, through shamanic rituals conquer his fears and uncover a suppressed memory he would much rather deny.
Singing cowboy Whip Wilson, the foreman on a cattle drive, quits his job to pursue five bank robbers who murdered his brother.
Female outlaw helps lawmen trap railroad bandits.