Outlaws of the Pandhandle was the last of Charles Starrett's "formula" westerns for Columbia: hereafter, Starrett would be seen only in the guise of frontier medico Steven Monroe or masked do-gooder The Durango Kid. For the moment, however, the star is cast as Jim Endicott, bound and determined to put an end to the underhanded activities of gin-mill operator Faro Jack Vaughn (Norman Willis). The villain's strategy is to get the local cowpunchers tanked up on rotgut that they'll prove to be easy pickings for a gang of rustlers-and will be unable to complete work on a railroad spur which will bypass the outlaws' hideaway.
A renowned former army scout is hired by ranchers to hunt down rustlers but finds himself on trial for the murder of a boy when he carries out his job too well. Tom Horn finds that the simple skills he knows are of no help in dealing with the ambitions of ranchers and corrupt officials as progress marches over him and the old west.
Bill Ramsbottom sells his English pub and drags his family off to Canada where he has inherited a ranch from his grandfather Wild Bill Ramsbottom. He ends up tangling with outlaw Black Jake, an Indian chief Blue Eagle, and the local law.
Rancher Clay Hardin arrives in San Antonio to search for and capture Roy Stuart, notorious leader of a gang of cattle rustlers. The vicious outlaw is indeed in the Texan town, intent on winning the affections of a beautiful chanteuse named Jeanne Starr. When the lovely lady meets and falls in love with the charismatic Hardin, the stakes for both men become higher.
Phoebe Titus is a tough, swaggering pioneer woman, but her ways become decidedly more feminine when she falls for California bound Peter Muncie. But Peter won't be distracted from his journey and Phoebe is left alone and plenty busy with villains Jefferson Carteret and Lazarus Ward plotting at every turn to destroy her freighting company. She has not seen the last of Peter, however.
US marshal Len Merrick saves Tim Keith from lynching at the hands of the Roden clan, and hopes to get him to Santa Loma for trial. Vindictive Ned Roden, whose son Ed was killed, still wants personal revenge, and Tim would like to escape before Ned catches up with him again. Can the marshal make it across the desert with Tim and his daughter? Even if he makes it, will justice be served?
Dare Rudd takes a shine to his cattleman cousin Tom's girlfriend who asks Tom to hire Dare to head the big cattle drive. Dare loses the money for the drive to cardsharps, but Tom wins it back, but Dare must save Tom's life.
Salvador accompanied by two friends of his father whom he calls uncles, they arrive at a fair in the village, there he meets Ana. When he wins a bet he is paid with a mortgaged house, to his surprise upon entering the hom he realizes that Ana and her mother live in it, provoking a funny entanglement with an explosive final.
When Jesse learns that Krager is cheating settlers, he and his gang rob trains to obtain money for them to purchase their land. Krager, finding a Jesse look alike in Burns, hires him to wreck havoc on the ranchers. When Jesse kills Burns he switches clothes and goes after the culprits.
Gene and Frog, out to stop a bunch of cattle rustlers, assume the identities of what they believe to be dead bandits, which soon gets them in big trouble.
Winters is after the Brand ranch, and his man Brett who is foreman there is rustling the Brand stock. But Tom is on to their game and breaks up their attempt to buy the ranch. When they plan to rustle their horses, Tom must not only rescue Danny Brand, who is their prisoner, but stop the rustlers.
Arriving at Medicine Bow, eastern schoolteacher Molly Woods meets two cowboys, irresponsible Steve and the "Virginian," who gets off on the wrong foot with her. To add to his troubles, the Virginian finds that his old pal Steve is mixed up with black-hatted Trampas and his rustlers...then finds himself at the head of a posse after said rustlers; and Molly hates the violent side of frontier life.
Three outlaws rob the stage and then flee. When their horses give out they murder some Indians to get fresh ones. But this puts the Indians on the war path and they have to take refuge in an Army fort to avoid them. The Indians then arrive offering peace if the three men are turned over to them. The fort's commanding Officer wants peace but the rules say the men must be tried in a white man's court leaving the Indians no choice but to attack.
A caravan of settlers is arriving and the ranchers intend to keep them out. It looks like a range war but Sheriff Jim gets the ranchers to accept the settlers. Kohler re-ignites the feud by making settler Winters appear to be a rustler and then by killing Winter's son. Once more the two sides appear headed for a war and Jim is caught in the middle.
Gene Autry and sidekick Frog Millhouse depart Madison Square Garden and NYC heading west for home in their car and a horse trailer carrying Gene's horse, Champion. They discover that Ronnie Willoughby, a young boy just off the boat from school in England, has hitched a ride, thinking that Gene and Frog were sent by his father to meet him. Ronnie thinks his father is a big rancher in the west and doesn't know that his father, Alfred Willoughby, is serving time in San Quentin prison because of a frame-up by the officials of a packing company. To keep the father from testifying against them, the packing company officials, Carter, Jenkins and Martin, have arranged for the boy to be kidnapped. Along the way a runaway bride, Joyce Halloway, and her young sister Patsy join the troupe.
Roy is a United States Marshal tracking down a counterfeiting ring and hunting down a mountain lion. Songs: "It's One Wonderful Day," "Rootin' Tootin' Cowboy," "Pancho's Rancho" and the title song.
A saddle-weary Steve Larkin, also the Duranko Kid, rides into Red Mound, a town filled with cattle rustlers. Cafe owner Smiley, befriends Steve and fills him in on the activities. Steve angers the rustler's leader, Flip Dugan when he purchases the old Atkins ranch which is supposedly haunted. Flip and his henchmen try to prevent the recording of the deed, but the Durango Kid and Deputy Marshal Tug Carter win the gun battle.
After being hit by rustlers, a group of Montana ranchers asks the governor to send state rangers for protection. State Ranger Rocky Lane becomes involved in a mystery surrounding a gang of horse rustlers and a young rancher who is blamed falsely for a killing. Lane helps uncover the real killers and unmasks the ringleader of the rustlers.
Protecting himself in an attack by rustlers, Rancher Steve Holden believes he has killed one of the attackers, young Bud Mathews, who in reality has warned Holden of the rustlers' approach. Unaware that Mathews was actually killed by rustler boss Cass Barton, Holden heads out to Mathews' home town where he plans to tell the boy's family of his death but instead uncovers a plan by a local businessman to force Mathews' father out of his ranch.
Cowboy infiltrates an outlaw gang to expose their rackets, but after he's ordered to kidnap a young girl, the gang finds out who he really is.