A Spanish cat is more interested in playing flamenco guitar than trying to catch the mouse El Magnifico (Jerry). Tom arrives from the States with world champion mouse-catching credentials to have a go.
Tom chases Jerry through the streets of Naples; they meet a local mouse who recognizes them from their cartoons and shows them around. Meanwhile, some local dogs are shadowing them.
Jerry and his diapered little mouse friend flood the kitchen, then use the freezer to turn it into a skating rink. Even though Tom finds a pair of ice skates, the mice have no problem outmaneuvering him.
Tom inherits $1,000,000 from an eccentric aunt on the condition that he not harm any living thing - even a mouse. And guess which mouse keeps following him around and pointing this out to him?
Tom settles in for a day at the beach with his sweety, accidentally ruining Jerry's day. Meanwhile, Tom's girl is paying more attention to the bodybuilders than to Tom.
A moment after a bottle of white shoe polish pours on Jerry, Tom hears on the radio that a white mouse, having swallowed an explosive, has escaped from an experimental laboratory and that slightest jar of the mouse could cause it to explode and blow up the entire city. It is then that Tom notices now-white Jerry and concludes it's the escapee.
The Bide A Wee Mouse Home has sent the orphan mouse Nibbles to spend Thanksgiving with Jerry. Unfortunately, Nibbles is always hungry.
Tom steals an egg from a mother duck's nest, but soon the resultant hatchling runs away from the cat and into a mouse hole, where it finds an able protector in Jerry.
A baby seal escapes from the circus and ends up in Jerry's backyard pool. Tom finds out soon enough, and when the circus offers a $10,000 reward, his goal is clear.
Professor Jerry teaches a course in how to outwit cats, but his pupil seems to know more than Jerry.
When a bulldog threatens Tom to keep away from his puppy, Jerry realizes that sticking close to the boy is the best way to keep away his feline tormentor. But Tom is not about to let the mouse evade him so easily.
Jerry's little duckling friend has packed his bag and is all set to fly south for the winter despite the book Jerry keeps showing him that points out that domestic ducks do not fly south, and despite his inability to fly at all.
Mammy Two-Shoes tells Tom and Butch that the cat who gets rid of the icebox-raiding, breadbox-invading mouse (Jerry) is the one who can stay.
Tom's new book on "how to catch a mouse" doesn't prove too helpful against Jerry; actually, Jerry seems to make better use of it than Tom.
Tom is playing with Jerry when a cute lady cat is delivered to Mammy for her to take care of. Tom is smitten at first sight.
The family dog warns Tom not to make any noise so he can take a nap. Jerry hears this and immediately devises plans to ensure that the dog's nap will be interrupted.
Tom fights with another cat over Jerry.
Tom is golfing, but having no success. Jerry insures that remains the case.
Tom chases Jerry into a bottle of invisible ink, and the now-invisible Jerry proceeds to have fun torturing Tom.
Jerry takes a midnight snack from the fridge unaware that Tom is watching him.