American professor John Holden arrives in London for a conference on parapsychology only to discover that the colleague he was supposed to meet was killed in a freak accident the day before. It turns out that the deceased had been investigating a cult lead by Dr. Julian Karswell. Though a skeptic, Holden is suspicious of the devil-worshiping Karswell. Following a trail of mysterious manuscripts, Holden enters a world that makes him question his faith in science.
Concerned about his friend's cocaine use, Dr. Watson tricks Sherlock Holmes into travelling to Vienna, where Holmes enters the care of Sigmund Freud. Freud attempts to solve the mysteries of Holmes' subconscious, while Holmes devotes himself to solving a mystery involving the kidnapping of Lola Deveraux.
After a meteorite unleashes a three-headed beast upon Tokyo, Mothra tries to unite with Godzilla and Rodan to battle the extraterrestrial threat.
While vacationing in St. Moritz, a British couple receive a clue to an imminent assassination attempt, only to learn that their daughter has been kidnapped to keep them quiet.
After Slip is drafted into the Marines, the rest of the gang volunteers so they can be with him. Sach discovers that the colonel knew his father and he is promoted. During a drill that he is putting the rest of the gang through, they find a soldier left for dead on the side of the road. Slip discovers a playing card next to the marine and traces it to Jolly Joe Johnson's gambling house. They suspect that the gambling house is cheating and set out to uncover the proof.
While under a hypnotic spell, Alfalfa thinks he's one of the Three Musketeers and challenges Butch to a duel.
Sherlock Holmes investigates when young women around London turn up murdered, each with a finger severed. Scotland Yard suspects a madman, but Holmes believes the killings to be part of a diabolical plot.
A detective starts spiraling out of control when a wave of gruesome murders with seemingly similar bizarre circumstances is sweeping Tokyo.
A playwright descended from the Borgia family becomes a murder suspect.
Lost Caverns Hotel bellhop Freddie Phillips is suspected of murder. Swami Talpur tries to hypnotize Freddie into confessing, but Freddie is too stupid for the plot to work. Inspector Wellman uses Freddie to get the killer (and it isn't the Swami).
The Bowery Boys find a lamp that has strange magic powers.
A violent gang enlists the help of a hypnotherapist in an attempt to locate a painting which somehow vanished in the middle of a heist.
Dr. Tony Flagg's friend Steven has problems in the relationship with his fiancée Amanda, so he persuades her to visit Tony. After some minor misunderstandings, she falls in love with him. When he tries to use hypnosis to strengthen her feelings for Steven, things get complicated.
Slip (Leo Gorcey), Sach (Huntz Hall), Bobby (Bobby Jordan), Whitey (William Benedict) and Chuck (David Gorcey) unsuccessfully try to sell a dilapidated car to a street cleaner for a fabulous amount, so they can get enough money to save Louie's (Bernard Gorcey) Malt Shop. Sidewalk photographer Cathy Smith (Teala Loring) snaps a pictures of three bank robbers as they are fleeing a robbery but when the Bowery Boys and Cathy realize that Sach is also in the photograph, they break into the photo lab to destroy the negative, which might make the police think Sach was involved in the robbery.
Slip invites his cousin Jimmy to stay with his family after he is released from prison. However, Jimmy soon gets mixed up with an auto-theft ring.
The Bowery Boys head west to clear Louie of an old murder charge that he had killed his gold-mine partner. Sach has the map to the gold mine painted on his back, and Blackjack McCoy has him kidnapped by Indian Joe. Gabe poses as a dangerous gunman, the Klondike Kid, while Slip is in charge of all the remaining loose ends.
Slip, Sach and the rest of the Bowery Boys enter a haunted house, where they engage in slapstick with a gorilla, a robot and a vampire
The Bowery Boys take on British crooks when one of them thinks he's inherited a title.
Five tales by Edgar Allan Poe come to life thanks to a pictorical style animation, five tales that exude madness, pestilence, murder and torture.
Elmer Fudd goes after Bugs using hypnotism, only the plan backfires.