Tom chases Jerry through the streets of Naples; they meet a local mouse who recognizes them from their cartoons and shows them around. Meanwhile, some local dogs are shadowing them.
A Spanish cat is more interested in playing flamenco guitar than trying to catch the mouse El Magnifico (Jerry). Tom arrives from the States with world champion mouse-catching credentials to have a go.
Jerry Mouse gets tired of living the country life and decides to head to the big city. However, the experience doesn't turn out quite like Jerry had expected.
An alley cat is foraging for food when he sees Tom's house and decides it's a rich haul. He dresses as a foundling baby and lands on the doorstep. Tom takes him in and Butch proceeds to raid the fridge between Tom's babying him. What he doesn't know is that Jerry's going to grab the ham Butch swiped every chance he gets.
Tom heads for a big city penthouse to become acquainted with a rich pretty female cat that lives there. He brings her Jerry as a gift and does some humiliating things to Jerry. Jerry, in turn, attracts the attention of another cat who also becomes interested in the female cat. It eventually turns into a fight between Tom and the other cat for the lady's hand but Jerry is the one who gets her in the end.
Tom's in love again, and Jerry's devil conscience reminds him of times this has happened in the past (which, of course, we see, in the form of clips from earlier shorts), and how that's been nothing but trouble for Jerry.
Jerry runs into a dog pound (and right on top of a napping Spike) to escape a rather mangy-looking Tom. To avoid being ripped to shreds, Tom borrows the head of a nearby dog statue. This easily fools the dogs, but not Jerry, and Tom keeps losing his newfound head...
Tom enters from stage left in white tie and tails, sits at the piano, gets his focus as the orchestra in the pit beneath him warms up, and begins to play Liszt's "Hungarian Rhapsody". Unbeknownst to Tom and the audience, Jerry is asleep across several of the high-note keys inside the instrument, so Tom's playing eventually wakes him. Jerry is pummeled by hammers, bounced by wires, and squeezed by Tom as the cat tries to play the concerto while dispensing with Jerry. Jerry's defensive antics add to the brio of the program and answer Tom with Jerry's own skillful musical attack. By the concerto's end, the duet leaves only one animal standing for the audience's applause.
Spike is guarding a private fishing hole - in his sleep. Tom sneaks in to do some fishing - with Jerry as bait. But one particularly vicious fish turns out to be more than Tom or Jerry bargained for, particularly when he wakes up Spike.
Tom ties up Spike and sneaks into the courtyard of the glamorous Toodles Galore with his bass, hoping to woo her with his song, much to the annoyance of a sleeping Jerry.
Spike the bulldog, grateful to Jerry for getting him out of the dogcatcher's van, offers to help the little mouse any time he whistles. Tom, Jerry's feline tormentor, seeks to overcome this new disadvantage.
Jerry crashes a vase onto Tom's head, which gets Mammy to throw Tom out. Jerry at first revels in his freedom, but soon tires of this, and, under a flag of truce, hatches a plan with Tom.
Tom is all set to eat Jerry when a hawk swoops down and grabs Jerry. To get Jerry back, Tom poses as a female hawk and quickly finds his new lover to be more than he bargained for.
Tom hears a ghost story on the radio and is spooked by it; Jerry notices this and takes advantage of it, using a variety of tricks to scare Tom.
Jerry narrates in voiceover: Tom has fallen hard for the cat next door, and competes with rich cat Butch for her affections. But Butch outspends Tom to a ludicrous level at every turn. Tom goes downhill after that, until we see him contemplating suicide.
The Easter bunny brings an egg for Tom and Jerry that hatches into the little duckling. He keeps getting into water he shouldn't: the aquarium, water cooler, bathtub, sink, as the boys keep rescuing it. They try to give the duck back to the Easter bunny - no go. They leave it in the pond at the park and think they're home free, until the duckling brings his friends home.
Jerry is far from Tom's servant here. Tom, shipwrecked, washes up on a tropical island. His first attempts at food - a coconut and a turtle - are much too hard. But he spots Jerry just before Jerry sees him, and soon has him in the frying pan. Jerry escapes to a cannibal village; when he sees Tom's frightened reaction, he has his plan. Using soot from a pot, he blackens himself, then threatens Tom and starts cooking him. But Jerry's plan - and tail, and un-blackened bottom - is exposed when his grass skirt comes off during his war dance. Jerry helicopters away using the bone in his hair, and leading Tom right into the real cannibals. But Jerry's triumph is short-lived, as a pygmy cannibal comes after him.
Tom's day at the beach doesn't start out well. First he gets his swimsuit caught in the door of the beach house, and doesn't realize it until his intended dive in the ocean sends him snapping back and crashing through the door. He runs out and tries again. This time he is so determined to jump in the water that when he does so, he doesn't notice the tide is out and that he is swimming in the sand, which is filled with broken bottles, tin cans and other debris. Later, he tries to win over a beautiful girl on the beach, but, being the boor he is, he annoys her by drinking her soda pop, eating her hot dog and munching loudly as he lays his head in her lap. Suddenly, a tomato flies through the air and lands on his head. So does a banana peel. Tom looks for the culprit and finds him in the girl's picnic basket. Jerry is inside, eating what he wants and tossing out the rest...
Tom and Jerry are in a bowling alley. Both spend a lot of time sliding on the well-polished lanes. Eventually, Jerry takes up residence among the pins and Tom tries to bowl him down.
Mammy Two-Shoes tells Tom and Butch that the cat who gets rid of the icebox-raiding, breadbox-invading mouse (Jerry) is the one who can stay.