2565 AD. Tom and Jerry are once again manipulating robot versions of themselves in space. Tom experiments with invisibility, a giant electromagnet, and explosives, with results from bad to disastrous.
Tom is on the canals of Venice, singing opera. He ends up on a cruise ship, where another cat tricks him out of Jerry (who Tom has just caught), then mirrors his every move. Eventually the cats start chasing each other.
A supply satellite arrives at the space station where Tom (despite his high-tech gadgets) is having no better luck than usual at catching Jerry before he gets the cheese.
Tom watches and studies films of some of his earlier encounters with Jerry, much like game films; he runs them backwards and stops them so he can study them more closely, all the while scribbling notes. Jerry pulls up a box of popcorn and watches, too. Tom notices Jerry and chases him into his hole. Tom designs a better mousetrap, but Jerry alters the plans, so it doesn't work any better than it did the first time the footage was used, in Designs on Jerry (1955).
Tom accompanies his owner, Clint Clobber, who has severe anger management issues, on a fishing trip.
This cartoon opens with a narrator introducing the ancient Greek Acropolis, describing its wealth and beautiful architecture. Tom is depicted as one of these inhabitants, an alley cat who lives in the shadows of Athens searching for food.
Tom's owner, Clint Clobber, is grilling steaks in his backyard. The steak's scent reaches Jerry, who is aroused by it and is led to the steak.
Jerry, tired of Tom's repeated attempts to kill him, leaves the house to join a space program. Tom tries to convince Jerry to stay, but to no avail.
Tom and Jerry are sleeping outside during the day when a yellow bird wearing a red helmet lands on Tom, waking him up. Although the bird brushes Tom's torso off and reacts politely like "pardon me", Tom goes after the bird, catches it, and proceeds to beat it up.
While chasing Jerry around a dock, Tom sees and instantly falls in love with a female cat. The female cat appears to return Tom's interest, so Tom sneaks aboard the ship the female cat and her owner have just boarded. Jerry follows Tom onto the boat and proceeds to interfere with Tom's subsequent flirtations.
In a 19th century fishing harbor, the captain of the Komquot is obsessed with catching the great white whale Dicky Moe. His obsession unnerves his crew so badly that they all desert the ship. Shortly afterward, the captain finds Tom searching for food in the harbor, knocks him out, and takes him aboard. Tom believes at first that he is going on a cruise, but the captain soon puts him to work scrubbing the deck.
When Jerry rustles cheese from the Dry Gulch General Store, Sheriff Mutt Dillin hires Tom, the fastest trap in the West.
Tom joins his owner on a hunting safari in Kenya. Jerry has hidden himself in the Clint's luggage, and Tom quickly sees him and attempts to get rid of him.
On a snowy night in the city, Jerry is comfortably asleep in his hole inside a penthouse, while Tom tries to keep from freezing to death in the alley below.
Jerry runs into the Metropolitan Opera, trying to evade Tom.
Tom, famous baritone Signor Thomasino Catti-Cazzaza, enthralls a concert audience with his rendition of "Largo al factotum", from Rossini's "Il Barbiere di Siviglia", while Jerry strives for sleep under the stage.
Jerry mixes and drinks a high-acceleration potion which renders him so fast that he eats all of Tom's food before the bewildered cat can even see him.
When a bulldog tells Jerry to "just whistle" any time that he needs him, Tom's in for big trouble until he puts earmuffs on the mutt.
Waif mouse Jerry, encrusted with snow, peers through a warmly lit window at Tom asleep by the fire in a room full of cheese.
Jerry heads out to his night job: drummer for an all-mouse rock band in the basement of a high-rise. They are loud enough to wake up Tom, despite his attempts to block the noise. Tom's attempts keep running him afoul of a rather mean-tempered dog.