After FBI agent Frank Lacrosse believes his son was kidnapped by a notorious serial killer, he travels to Amarillo, Texas, where he believes the murderer is in hiding. Although officially taken off the case because of its personal significance to him, Frank continues to pursue the killer, causing concern for local sheriff Buck Olmstead. When another victim pops up at a nearby car garage, Frank knows that he is as close as he'll ever be to tracking down the elusive killer.
On their way to an afternoon on the lake, husband and wife Andrzej and Krystyna nearly run over a young hitchhiker. Inviting the young man onto the boat with them, Andrzej begins to subtly torment him; the hitchhiker responds by making overtures toward Krystyna. When the hitchhiker is accidentally knocked overboard, the husband's panic results in unexpected consequences.
Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.
Thomas hitchhikes from Hamburg to Munich where he meets his ex-girlfriend, Peggy. Thomas doesn't have a bed for the night and goes home with Peggy, not knowing that she and her four roommates have all made a strange pact.
While driving through the New Mexico Desert during a rainy night, college students Jim Halsey and his girlfriend Grace Andrews give a ride to a hitchhiker. While in their car, the stranger proves to be a psychopath threatening the young couple with a knife, but Jim successfully throws him out of the car. This sets off a chain of events that will change all of their lives forever.
On a stormy night, young Jim, who transports a luxury car from Chicago to California to deliver it to its owner, feeling tired and sleepy, picks up a mysterious hitchhiker, who has appeared out of nowhere, thinking that a good conversation will help him not to fall asleep. He will have enough time to deeply regret such an unmeditated decision.
Zia, distraught over breaking up with his girlfriend, decides to end it all. Unfortunately, he discovers that there is no real ending, only a run-down afterlife that is strikingly similar to his old one, just a bit worse. Discovering that his ex-girlfriend has also "offed" herself, he sets out on a road trip to find her.
When a former fistfighter Madis leaves the prison, he feels he will get another chance in life. Nothing can go wrong this time. Madis will be accompanied by his nephew who has something completely opposite in his mind. A game begins where both the weak and the strong get more and more opportunities.
Kowalski works for a car delivery service, and takes delivery of a 1970 Dodge Challenger to drive from Colorado to San Francisco. Shortly after pickup, he takes a bet to get the car there in less than 15 hours.
A couple's car runs out of fuel on a lonely country road. When the husband returns to his pregnant wife with the fuel, he's in for a deadly surprise.
A young man is in a race against time as he searches for a cure after becoming infected with a virus that will eventually turn him into a blood-sucking vampire.
Two college friends, traveling in Europe, find themselves rivals for the attentions of a mysterious woman.
Gösta is a lorry driver and has been married to Birgitta for eight years. Their marriage is only held together by their daughter. Gösta picks up girls along the roads and during a drive to Malmö he stumbles on the singing actress Irene. Gösta is captivated by her romantic presence and her joy of life. Besides picking up women, Gösta is sometimes affected by sudden seizures. His wife is unaware of this.
The life of Al Roberts, a pianist in a New York nightclub, turns into a nightmare when he decides to hitchhike to Los Angeles to visit his girlfriend.
A sadistic serial killer terrorizes a couple driving on a rural highway in Texas while killing numerous people and framing them for his killings.
A young woman stumbles into a nightmare land of hijacking and humiliation while driving cross-country from California to New York.
After she leaves her cheating husband, Susan Reed embarks on a cross-country road trip where she falls victim to a series of mishaps that land her behind bars in the redneck Macon County Jail. Once inside, she's subjected to endless acts of brutality from the guards and inmates alike. Things go from bad to worse when she's forced to defend herself against a rapist with tragic results. No longer truly "innocent," when the opportunity arises Susan flees with fellow prisoner Coley.
Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
Joe and Paul Fabrini are Wildcat, or independent, truck drivers who have their own small one-truck business. The Fabrini boys constantly battle distributors, rivals and loan collectors, while trying to make a success of their transport company.
One evening, Hammer gives a ride to Christina, an attractive hitchhiker on a lonely country road, who has escaped from the nearby lunatic asylum. Thugs waylay them and force his car to crash. When Hammer returns to semi-consciousness, he hears Christina being tortured until she dies. Hammer, both for vengeance and in hopes that "something big" is behind it all, decides to pursue the case.