On their cross-country drive, a married couple, Jeff and Amy Taylor, experience car trouble after their SUV breaks down. Stranded in the New Mexico desert, the two catch a break when a passing truck driver offers Amy a ride to a nearby café to call for help. Meanwhile, Jeff is able to fix the car and make his way to the café, but Amy isn't there. He tracks down the trucker ― who tells the police he's never seen Jeff or his wife before. Jeff then begins a desperate, frenzied search for Amy.
Theo is having some bad luck. His barely paid-for truck has been stolen, and credit collectors are after him. The chase leads him across Europe.
Long-haul driver Hannes (Manfred Krug) picks up a young hitchhiker, Herb (Jaecki Schwarz), who had a falling-out with his parents after dropping out of college and now travels around doing odd jobs. After a series of adventures, they are joined by Johanna (Jutta Hoffmann) and her child, who missed their bus and need a ride to Berlin. Johanna has left her husband so that he can reflect on their broken relationship and both men gradually begin to fall in love with her.
After a remote diamond mine collapses in far northern Canada, an ice road driver must lead an impossible rescue mission over a frozen ocean to save the trapped miners.
Old Mr. Cohen (Paul Graetz) simply walks away from his London department store, leaving his sons to run it.
Truck driver searches for his brother, who has disappeared in a town run by a corrupt judge.
Trucker Rubber Duck and his buddies Pig Pen, Widow Woman and Spider Mike use their CB radios to warn one another of the presence of cops. But conniving Sheriff Wallace is hip to the truckers' tactics, and begins tricking the drivers through his own CB broadcasts. Facing constant harassment from the law, Rubber Duck and his pals use their radios to coordinate a vast convoy and rule the road.
In Texas, the aspirant actress Nicole Carrow runs away home to Los Angeles with her boyfriend Jess Hilts. They drive through a shortcut in an old road, and when they park in a rest stop, Jess is abducted by the sadistic driver of an old yellow truck. Along the night, Nicole is threatened by the sick maniac, while mysterious things happen to her in the place.
Lincoln Hawk a hard-luck big-rig trucker takes us under the glaring Las Vegas lights for all the boisterous action of the World Armwrestling Championship. Relying on wits and willpower, Hawk tries to rebuild his life by capturing the first-place prize money, and the love of the son he abandoned years earlier into the keeping of his rich, ruthless father-in-law.
The Italian driver Caruso, who usually secretly spoils the daughter of his boss, Oskar Schnell, is sent on the trip with his buddy Klaus. However, the boss doesn't suspect a bit that the two make plenty of erotic stops.
A newly married couple, en route to their honeymoon, stop at a service station in the middle of the night. When Zoran disappears to make a phone call and fails to return, Dawn begins to wonder just how well she knows her new husband.
Truck driver Jack Burton gets embroiled in a supernatural battle when his best friend Wang Chi's green-eyed fiancée is kidnapped by henchmen of the sorcerer Lo Pan, who must marry a girl with green eyes in order to return to the human realm.
A long-haul trucker turns to YouTube to combat loneliness and social isolation. Under the handle “MsDivaTrucker43,” she discovers a supportive community of women who share her struggles of life in the margins. It is difficult for women in an industry that is 96% male to see themselves succeeding. Tamara's words of wisdom and encouragement offer women a model and a path forward.
While driving to Las Vegas for the bachelor party of her sister Melissa and her fiance Bobby, Kayla stops the car at a gas station to meet her date, Nik, a guy she met on the internet. Nik convinces her to take a secondary road under the protest of Bobby but the car breaks down. They find a house in the middle of nowhere and decide to take the car parked in the house's garage to the next city...
Joe and Paul Fabrini are Wildcat, or independent, truck drivers who have their own small one-truck business. The Fabrini boys constantly battle distributors, rivals and loan collectors, while trying to make a success of their transport company.
Three young people check into the Meadow View Inn for a night's rest, fully unaware of the inn's sick-minded employees and their nefarious intentions.
An ex-con takes a job driving a truck cross country. What he doesn't know is that the truck is filled with illegal weapons and now he must fight to survive and save his family.
Three young people on a road trip from Colorado to New Jersey talk to a trucker on their CB radio, then must escape when he turns out to be a psychotic killer.
In this humorous paean to the joys of food, a pair of truck drivers happen onto a decrepit roadside shop selling ramen noodles. The widowed owner, Tampopo, begs them to help her turn her establishment into a paragon of the "art of noodle-soup making". Interspersed are satirical vignettes about the importance of food to different aspects of human life.
Commentator-comic Bill Maher plays devil's advocate with religion as he talks to believers about their faith. Traveling around the world, Maher examines the tenets of Christianity, Judaism and Islam and raises questions about homosexuality, proof of Christ's existence, Jewish Sabbath laws, violent Muslim extremists.