Cursed since childhood, dentist Charlie Logan cannot find the right woman. Even worse, he learns that each of his ex-girlfriends finds true love with the man she meets after her relationship with him ends. Hearing of Charlie's reputation as a good-luck charm, women from all over line up for a quick tryst. But when Charlie meets the woman of his dreams, he must find a way to break the curse or risk losing her to the next man she meets.
In Los Angeles, Max Carlyle makes a good living directing commercials and has a happy home life with his wife, Mimi, and two children. When Carlyle travels to New York City to visit his friend Charlie, who has been diagnosed with AIDS, he has repeat run-ins with a beautiful woman, Karen, and eventually sleeps with her. Though he goes home the next day and doesn't return until a year later, Carlyle's infidelity still lingers.
Tongue-in-cheek look at 20-something singles clubbing and partying in L.A. Voice-over narration, charts and graphs, and visits to a research laboratory punctuate the story of a single night when groups of friends go out, drink alcohol, take drugs, dance and talk, and look for someone to go home with.
Lovestruck Dustin is dating Alexis, his ideal girlfriend, but when she dumps him for coming on too strong, Dustin takes drastic measures to win her back. He asks his best friend Tank to take her on the worst rebound date imaginable - his side job - so that she will come running back to him, and Tank reluctantly agrees. However, Alexis is more than a match for Tank's shock tactics and he begins to really fall for her, leaving him torn between loyalty to Dustin and his growing attraction toward Alexis.
Tom and Hannah have been platonic friends for 10 years. He's a serial dater, while she wants marriage but hasn't found Mr. Right. Just as Tom is starting to think that he is relationship material after all, Hannah gets engaged. When she asks Tom to be her 'maid' of honor, he reluctantly agrees just so he can attempt to stop the wedding and woo her.
A married man's one-night stand comes back to haunt him when that lover begins to stalk him and his family.
To call or not to call? For young Cora it's not a question. In fact, after the first date you may never call the guy, even if it was the best sex of your life! It's him who must beg for a meeting - and not later than 72 hours after. Otherwise - delete it from memory.
Mikaela has undergone gender reassignment and is now a woman. One night at a bar, she meets a guy and takes him back to her place.
Holidaymakers arriving in a Club Med camp on the Ivory Coast are determined to forget their everyday problems and emotional disappointments. Games, competitions, outings, bathing and sunburn accompany a continual succession of casual affairs.
A player in a famous orchestra finds sexual experiences with a Russian opera singer, which he enjoys much because his wife has just left due to the fact that he has purchased a porno movie. The orchestra player gets known to his neighbour, a gay man having also relationship troubles, and together they are trying hard to find a way how to go on with their lifes.
Maria is a student at the university of Essen, Germany, living and working in a gray, unpleasant, and anonymous environment. While she has little problem finding someone for a one night stand, she rebuffs her lovers in such a rude way that they actually don't know what's going on. But what seems to be a negative attitude at first glance is in fact much worse: Maria is suffering from borderline syndrome, a serious psychotic disease that makes her fail to develop a continuous, reliable personality, from her own perspective as well as from the perspective of those she meets. Then one day, she bumps into Jan, a student who falls in love with her without delay. He's awaiting a hard time when he has to learn how hard it is to stay loyal and faithful to a person who, in her own words, "has a different world inside of her head" and who feels that "there is something inside of me that eats me up."
When Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful Rachel Jansen, Peter is shocked to see not only Aldous Snow in Hawaii, but also Sarah Marshall.
When a young accountant is devastated after discovering his inspiringly beautiful girlfriend is cheating on him, his best friend, who's engaged to a girl he doesn't love, convinces him to go on a "run" and sleep with as many women as he can to get over his heart break.
A loving couple Martin and Lea have some problems with each other too.
An immature, newly unemployed comic must navigate the murky waters of adulthood after her fling with a graduate student results in an unplanned pregnancy.
A slacker and a career-driven woman accidentally conceive a child after a one-night stand. As they try to make the relationship work, they must navigate the challenges of parenthood and their differences in lifestyle and maturity.
An alcoholic becomes involved in a fellow A.A. member's plan to kidnap her young son from the boy's wealthy grandfather.
A thirty-something southern woman searches for love, despite the burdens she carries with her.
An ambitious reporter probes the reasons behind the sudden split of a 1950s comedy team.
What happens when two profoundly lonely men who are strangers, one older and gay, and the second younger and questioning, take one last chance at making a sincere human connection? Based on true events in the life of the writer/director.