Homer is an orphan who was never adopted, becoming the favorite of orphanage director Dr. Larch. Dr. Larch imparts his full medical knowledge on Homer, who becomes a skilled, albeit unlicensed, physician. But Homer yearns for a self-chosen life outside the orphanage. What will Homer learn about life and love in the cider house? What of the destiny that Dr. Larch has planned for him?
Yuri Orlov is a globetrotting arms dealer and, through some of the deadliest war zones, he struggles to stay one step ahead of a relentless Interpol agent, his business rivals and even some of his customers who include many of the world's most notorious dictators. Finally, he must also face his own conscience.
When the trail goes cold on a murder investigation of a policeman, an undercover narcotics officer is lured back to the force to help solve the case.
Stripped of his medical license after performing an operation while high on amphetamines, famed LA surgeon Dr Eugene Sands abandons his former life only to find himself crossing paths with Raymond Blossom, an infamous counterfeiter. Employed as a "gun-shot doctor" when Raymond's associates cannot risk visiting a hospital, Eugene is lured deep into the criminal world and becomes entangled with his boss's girlfriend.
In 1965, a young woman with dreams of becoming a writer has a son at the age of 15 and struggles to make things work with the drug-addicted father.
A New York press agent must scramble when his major client becomes embroiled in a huge scandal.
While investigating a young nun's rape, a corrupt New York City police detective, with a serious drug and gambling addiction, tries to change his ways and find forgiveness.
Vincent LaMarca is a dedicated and well-respected New York City police detective who has gone to great lengths to distance himself from his past, but then makes the terrible discovery that his own son has fallen into a life of crime.
A college freshman returns to Los Angeles for Christmas at his ex-girlfriend's request, but discovers that his former best friend has an out-of-control drug habit.
Rick (Rutger Hauer), a disaffected sailor turned hard drinking womanizer, returns home from six months at sea to find his wife (Corrigan), whom he was deeply in love, has unexpectedly left him and is now a junkie whore. Devastated, he tries to ease his pain with booze and cheap thrills. His wife's best friend (Dagmar Lassander) makes a move on him, and when he spurns her (after scewing her first, naturally) she plots her revenge. She does so in an ingenious way, by exploiting a fantasy woman of his, but her plan backfires with tragic consequences.
After a friend overdoses, Spoon and Stretch decide to kick their drug habits and attempt to enroll in a government detox program. Their efforts are hampered by seemingly endless red tape, as they are shuffled from one office to another while being chased by drug dealers and the police.
Substance-addicted Hollywood actress, Suzanne Vale is on the skids. After a spell at a detox centre her film company insists as a condition of continuing to employ her that she live with her mother, herself once a star and now a champion drinker. Such a set-up is bad news for Suzanne who has struggled for years to get out of her mother's shadow, and who still treats her like a child. Despite these and other problems, Suzanne begins to see the funny side of her situation, and also realises that not only do daughters have mothers—mothers do too.
The son of a wealthy businessman finds solace in drugs and alcohol when he breaks up with his childhood love.
Hotshot real estate salesman Daryl has a bad cocaine habit. After embezzling his company's money, he wakes up next to a girl who overdosed. To hide from the police, he checks into a rehabilitation program guaranteeing anonymity. Under the mentorship of counselor Craig, Daryl accepts that he has a substance abuse problem. As he falls in love with fellow patient Charlie, Daryl begins committing to a newly sober life.
After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.
Two childhood friends from South Boston turn to crime as a way to get by, ultimately causing a strain in their personal lives and their friendship.
Thumbsucker - Behind the Scenes
A young boy trying to deal with his mother's heroin addiction befriends a waitress who helps him cope with the tough situation.
Sammy is a teenage cutter living with her meth addicted mother in a trailer on the Indian Ridge Reservation. Her mother's boyfriend is a drug dealer using the reservation as a cover for his drug trafficking. David, Sammy's best friend, is a foster youth and helps her to escape from this dysfunctional life she's had to endure since her father died.
January 1978. After their success in England, the punk rock band Sex Pistols venture out on their tour of the southern United States. Temperamental bassist Sid Vicious is forced by his band mates to travel without his troubled girlfriend, Nancy Spungen, who will meet him in New York. When the band breaks up and Sid begins his solo career in a hostile city, the turbulent couple definitely falls into the depths of drug addiction.