A Spanish cat is more interested in playing flamenco guitar than trying to catch the mouse El Magnifico (Jerry). Tom arrives from the States with world champion mouse-catching credentials to have a go.
Tom chases Jerry through the streets of Naples; they meet a local mouse who recognizes them from their cartoons and shows them around. Meanwhile, some local dogs are shadowing them.
Jerry and his diapered little mouse friend flood the kitchen, then use the freezer to turn it into a skating rink. Even though Tom finds a pair of ice skates, the mice have no problem outmaneuvering him.
Tom inherits $1,000,000 from an eccentric aunt on the condition that he not harm any living thing - even a mouse. And guess which mouse keeps following him around and pointing this out to him?
Tom sells Jerry to a local pet store that's buying white mice. Yes, Jerry's brown, but a little paint fixes that.
Jerry Mouse gets tired of living the country life and decides to head to the big city. However, the experience doesn't turn out quite like Jerry had expected.
Tom settles in for a day at the beach with his sweety, accidentally ruining Jerry's day. Meanwhile, Tom's girl is paying more attention to the bodybuilders than to Tom.
A moment after a bottle of white shoe polish pours on Jerry, Tom hears on the radio that a white mouse, having swallowed an explosive, has escaped from an experimental laboratory and that slightest jar of the mouse could cause it to explode and blow up the entire city. It is then that Tom notices now-white Jerry and concludes it's the escapee.
A baby woodpecker mistakes Jerry for his mother. The mouse rejects the newly hatched bird but soon finds himself protecting it against his feline nemesis, Tom.
During yet another pursuit of Jerry, Tom ends up being killed when an upright piano slides down the stairs and slams into him. He meets a feline St. Peter at the gate of the Heavenly Express, but is initially turned away due to his constant torture. However, he will be allowed onto the train if he can have Jerry sign a letter of forgiveness within one hour. If not, it's Hell for Tom. Will he go up or down?
Spike has just put Tyke to bed for his nap when Tom and Jerry chase out the door to Tyke's crib, waking him up. This gives Tyke an attack of hiccups. Spike warns Tom not to wake him up again, which of course is all Jerry needs.
Tom has been out late carousing with his chums. When he gets home, Mammy won't take any excuses, and insists he stay awake; Jerry, overhearing, thus tries a number of schemes to get Tom to sleep.
Spike has just washed his pup. Tom and Jerry's chase knocks him into a mud puddle. Spike makes Tom clean him up again and promise to keep him clean which of course is Jerry's opening to get Tom in trouble.
Nobody's home, so Tom invites his alley cat friends in to look at home movies (clips from earlier cartoons where Tom gets the drop on Spike). While they're showing them, Spike sneaks in.
Spike is building his dream house when Tom crashes into it mid-chase. Of course, Jerry then takes every opportunity to route the chases through the construction project.
Tom reads Jerry's best selling book, "Life with Tom" and experiences some flashbacks.
When a bulldog threatens Tom to keep away from his puppy, Jerry realizes that sticking close to the boy is the best way to keep away his feline tormentor. But Tom is not about to let the mouse evade him so easily.
The Bide A Wee Mouse Home has sent the orphan mouse Nibbles to spend Thanksgiving with Jerry. Unfortunately, Nibbles is always hungry.
Tom steals an egg from a mother duck's nest, but soon the resultant hatchling runs away from the cat and into a mouse hole, where it finds an able protector in Jerry.
A baby seal escapes from the circus and ends up in Jerry's backyard pool. Tom finds out soon enough, and when the circus offers a $10,000 reward, his goal is clear.