Jerry narrates in voiceover: Tom has fallen hard for the cat next door, and competes with rich cat Butch for her affections. But Butch outspends Tom to a ludicrous level at every turn. Tom goes downhill after that, until we see him contemplating suicide.
The Easter bunny brings an egg for Tom and Jerry that hatches into the little duckling. He keeps getting into water he shouldn't: the aquarium, water cooler, bathtub, sink, as the boys keep rescuing it. They try to give the duck back to the Easter bunny - no go. They leave it in the pond at the park and think they're home free, until the duckling brings his friends home.
Tom is shipwrecked on an island, which is inhabited by at least one mouse - Jerry. To thwart the hungry cat, Jerry disguises himself as a cannibal.
Tom subjects Jerry to his usual harassment; but the cat finds a new enemy, and the mouse finds a new friend, in the canary of the house.
Mammy Two-Shoes replaces Tom with a younger cat who is a lightning-quick mouser. Tom and Jerry form an alliance in order to get rid of this dangerous newcomer.
Tom is given the task of guarding the fridge during the night by Mammy-Two-Shoes, but as soon as he has started he is tricked by Jerry into falling into the basement, where he lands in a barrel of cider. Now drunk, Tom staggers around in the house getting up to no good with Jerry.
Jasper is given an ultimatum by his master: break one more thing and you're out. Rodent Jerry does his best to make sure that his tormentor "gets the boot".
Chased by Tom around the barnyard, Jerry takes refuge under a hen, who, in her nest, is sitting on eggs. Tom has to figure out ways to get Jerry out from under the protective hen.
Jerry finds himself in charge of a foundling mouse called Nibbles, who is eager to steal milk from Tom's bowl and oblivious to the danger.
Tom is all set to eat Jerry when a hawk swoops down and grabs Jerry. To get Jerry back, Tom poses as a female hawk and quickly finds his new lover to be more than he bargained for.
Tom hears a ghost story on the radio and is spooked by it; Jerry notices this and takes advantage of it, using a variety of tricks to scare Tom.
Tom and Jerry need to repeatedly come to the rescue when a teenage babysitter, supposed to be looking after the baby, is more interested in talking on the telephone than in paying attention to the baby who keeps crawling away.
Spike is showing his son Tyke how to barbecue when his cooking is disrupted by a typical Tom-and-Jerry chase.
Tom drowns in a lake and sinks to the bottom. There, he finds a mermouse, which he tries to capture and eat.
Tom has plans to take a nice long nap in a hammock, but Jerry has gotten there first and is snoozing happily, so the two fight it out to see who gets to sleep there.
Tom's new book on "how to catch a mouse" doesn't prove too helpful against Jerry; actually, Jerry seems to make better use of it than Tom.
Tom fights with another cat over Jerry.
Tom is golfing, but having no success. Jerry insures that remains the case.
Tom chases Jerry into a bottle of invisible ink, and the now-invisible Jerry proceeds to have fun torturing Tom.
Jerry takes a midnight snack from the fridge unaware that Tom is watching him.