Tom and Jerry need to repeatedly come to the rescue when a teenage babysitter, supposed to be looking after the baby, is more interested in talking on the telephone than in paying attention to the baby who keeps crawling away.
Tom is the official cat on the cruise ship S.S. Aloha, but he'll be kicked off if the captain finds even one mouse. That one, of course, is Jerry, who sneaks on board just before sailing.
Tom is in a pool hall after hours; as he soon discovers, Jerry is sleeping in the corner pocket. Tom chases Jerry around the table and the rest of the pool hall. Tom's energetic game of pool is more than Jerry can cope with. Soon, the table becomes a battlefield.
Tom's in love again, and Jerry's devil conscience reminds him of times this has happened in the past (which, of course, we see, in the form of clips from earlier shorts), and how that's been nothing but trouble for Jerry.
An alley cat is foraging for food when he sees Tom's house and decides it's a rich haul. He dresses as a foundling baby and lands on the doorstep. Tom takes him in and Butch proceeds to raid the fridge between Tom's babying him. What he doesn't know is that Jerry's going to grab the ham Butch swiped every chance he gets.
Tom heads for a big city penthouse to become acquainted with a rich pretty female cat that lives there. He brings her Jerry as a gift and does some humiliating things to Jerry. Jerry, in turn, attracts the attention of another cat who also becomes interested in the female cat. It eventually turns into a fight between Tom and the other cat for the lady's hand but Jerry is the one who gets her in the end.
Spike is showing his son Tyke how to barbecue when his cooking is disrupted by a typical Tom-and-Jerry chase.
Tom drowns in a lake and sinks to the bottom. There, he finds a mermouse, which he tries to capture and eat.
Tom has plans to take a nice long nap in a hammock, but Jerry has gotten there first and is snoozing happily, so the two fight it out to see who gets to sleep there.
Tom designs a better mousetrap that would have made Rube Goldberg jealous. While he sleeps, the mouse that Tom drew wakes Jerry and they get chased by the cat Tom drew. As Tom awakes, they make a strategic alteration to the design.
Jerry runs into a dog pound (and right on top of a napping Spike) to escape a rather mangy-looking Tom. To avoid being ripped to shreds, Tom borrows the head of a nearby dog statue. This easily fools the dogs, but not Jerry, and Tom keeps losing his newfound head...
Chased by Tom around the barnyard, Jerry takes refuge under a hen, who, in her nest, is sitting on eggs. Tom has to figure out ways to get Jerry out from under the protective hen.
Tom subjects Jerry to his usual harassment; but the cat finds a new enemy, and the mouse finds a new friend, in the canary of the house.
Mammy Two-Shoes replaces Tom with a younger cat who is a lightning-quick mouser. Tom and Jerry form an alliance in order to get rid of this dangerous newcomer.
Tom is given the task of guarding the fridge during the night by Mammy-Two-Shoes, but as soon as he has started he is tricked by Jerry into falling into the basement, where he lands in a barrel of cider. Now drunk, Tom staggers around in the house getting up to no good with Jerry.
Jasper is given an ultimatum by his master: break one more thing and you're out. Rodent Jerry does his best to make sure that his tormentor "gets the boot".
Tom is all set to eat Jerry when a hawk swoops down and grabs Jerry. To get Jerry back, Tom poses as a female hawk and quickly finds his new lover to be more than he bargained for.
Tom hears a ghost story on the radio and is spooked by it; Jerry notices this and takes advantage of it, using a variety of tricks to scare Tom.
Jerry finds himself in charge of a foundling mouse called Nibbles, who is eager to steal milk from Tom's bowl and oblivious to the danger.
Jerry narrates in voiceover: Tom has fallen hard for the cat next door, and competes with rich cat Butch for her affections. But Butch outspends Tom to a ludicrous level at every turn. Tom goes downhill after that, until we see him contemplating suicide.