When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.
Ben Sanderson, an alcoholic Hollywood screenwriter who lost everything because of his drinking, arrives in Las Vegas to drink himself to death. There, he meets and forms an uneasy friendship and non-interference pact with prostitute Sera.
In early-1970s Las Vegas, Sam "Ace" Rothstein gets tapped by his bosses to head the Tangiers Casino. At first, he's a great success in the job, but over the years, problems with his loose-cannon enforcer Nicky Santoro, his ex-hustler wife Ginger, her con-artist ex Lester Diamond and a handful of corrupt politicians put Sam in ever-increasing danger.
John Gage offers a down-on-his-luck yuppie husband $1 million for the opportunity to spend the night with the man's wife.
During a wild vacation in Las Vegas, career woman Joy McNally and playboy Jack Fuller come to the sober realization that they have married each other after a night of drunken abandon. They are then compelled, for legal reasons, to live life as a couple for a limited period of time. At stake is a large amount of money.
A supermarket clerk decides to step in for an absent drug dealer, setting off an explosive, comedic chain of events.
Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
A professional poker player whose astounding luck at the table fails to translate into his lonesome love life attempts to win the World Series of Poker while simultaneously earning the affections of a beautiful Las Vegas singer.
New York gangster Ben 'Bugsy' Siegel takes a brief business trip to Los Angeles. A sharp-dressing womanizer with a foul temper, Siegel doesn't hesitate to kill or maim anyone crossing him. In L.A. the life, the movies, and most of all strong-willed Virginia Hill detain him while his family wait back home. Then a trip to a run-down gambling joint at a spot in the desert known as Las Vegas gives him his big idea.
Fresh to Las Vegas with no connections, Nomi Malone takes a job as an exotic dancer. Her talents are quickly noticed by Cristal, a headlining dancer who senses an opportunity to bolster her own act. But Nomi won’t play second fiddle and soon begins her venomous path to the top, ruthlessly backstabbing anyone who gets in her way.
Bernie works at a Las Vegas casino, where he uses his innate ability to bring about misfortune in those around him to jinx gamblers into losing. His imposing boss, Shelly Kaplow, is happy with the arrangement. But Bernie finds unexpected happiness when he begins dating attractive waitress Natalie Belisario.
It was an ingenious enough plan: rob the Riviera Casino's count room during an Elvis impersonator convention. But Thomas Murphy decided to keep all the money for himself and shot all his partners, including recently-freed ex-con Michael Zane. With $3.2 million at stake, the Marshals Service closing in, Michael must track down Murphy.
A rich girl steals her dad's Rolls Royce and heads off to Las Vegas to get married. However, her angry parents, a jealous suitor, and a bunch of reward seekers are determined to stop her.
TV buff, Jack Fremont, uses his knowledge to stop a nuclear attack by a Russian seeking recognition for his work in television and espionage.
When three friends finally come to after a raucous night of bachelor-party revelry, they find a baby in the closet and a tiger in the bathroom. But they can't seem to locate their best friend, Doug – who's supposed to be tying the knot. Launching a frantic search for Doug, the trio perseveres through a nasty hangover to try to make it to the church on time.
Jack is caught with the wife of his employer, a Vegas thug. The thug sends goons after Jack, who convinces his best friend, Pilot, to flee with him. Pilot insists that they head for Seattle, but doesn't tell Jack why. The goons learn from Pilot's drug source where the youths are headed, and they follow, hell bent on breaking Jack's feet. On the road, Jack and Pilot give a ride to Cassie, a distressed young woman. She and Jack hit it off. They pick up an aging stoner headed to Seattle for Kurt Cobain's memorial, and they help a circus sideshow family. Why is Pilot so set on Seattle, will the goons catch Jack, and is there any way the friends' competing needs can be resolved?
Rover, a street-smart dog owned by a Las Vegas showgirl is dumped off Hoover Dam by the showgirl's boyfriend. Rather than drowning, Rover winds up in your basic idyllic farm in a classic city-boy-in-country shtick.
Corporate downsizing expert Ryan Bingham spends his life in planes, airports, and hotels, but just as he’s about to reach a milestone of ten million frequent flyer miles, he meets a woman who causes him to rethink his transient life.
When newlyweds visit Las Vegas, the wife's shady past comes to the surface.
Four grumpy old men go on a road trip from their retired life in Florida to the excitement of Las Vegas in order to stop one of their daughters from marrying the wrong guy.