Eccentric consulting detective Sherlock Holmes and Doctor John Watson battle to bring down a new nemesis and unravel a deadly plot that could destroy England.
Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".
Holmes and Dr. Watson take on the case of a beautiful woman whose husband has vanished. The investigation proves strange indeed, involving six missing midgets, villainous monks, a Scottish castle, the Loch Ness monster, and covert naval experiments.
Holmes goes on the trail of a Rembrandt painting, stolen by a drug-addicted artist.
When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.
In 1947, long-retired and near the end of his life, Sherlock Holmes grapples with an unreliable memory and must rely on his housekeeper's son as he revisits the still-unsolved case that led to his retirement.
The corpse of a shabbily dressed young woman has been discovered in the mud flats of the Thames at low tide. Police assume she's a prostitute, but Dr. Watson suspects something more and goes to his old friend Holmes, now retired and at very loose ends.
The millionaire's child is kidnapped. Sherlock Holmes after many thrilling adventures and narrow escapes rescues the child.
Holmes and Watson board a passenger train bound from London to Edinburgh, to guard the Star of Rhodesia, an enormous diamond worth a fortune belonging to an elderly woman of wealth; but within the first hour of the trip, the woman's son is murdered and the diamond stolen and any of the passengers in their car could be the killer thief.
A convicted thief in Dartmoor prison hides the location of the stolen Bank of England printing plates inside three music boxes. When the innocent purchasers of the boxes start to be murdered, Holmes and Watson investigate.
A young woman turns to Holmes for protection when she's menaced by an escaped killer seeking missing treasure. However, when the woman is kidnapped, Holmes and Watson must penetrate the city's criminal underworld to find her.
England, at the start of World War Two. Mysterious wireless broadcasts, apparently from Nazi Germany are heard over the BBC. They warn of acts of terror in England, just before they take place. Baffled, the Defense Committee call in Sherlock Holmes.
On his uncle's death Sir Henry Baskerville returns from Canada to take charge of his ancestral hall on the desolate moors of Devonshire, and finds that Sherlock Holmes is there to investigate the local belief that his uncle was killed by a monster hound that has roamed the moors since 1650, and is likely to strike again at Sir Henry.
After spending decades living in the shadow of his more famous and successful sibling, Consulting Detective Sigerson Holmes (Wilder) is called upon to help solve a crucial case that leads him on a hilarious trail of false identities, stolen documents, secret codes... and exposed backsides.
Concerned about his friend's cocaine use, Dr. Watson tricks Sherlock Holmes into travelling to Vienna, where Holmes enters the care of Sigmund Freud. Freud attempts to solve the mysteries of Holmes' subconscious, while Holmes devotes himself to solving a mystery involving the kidnapping of Lola Deveraux.
When Watson reads from the newspaper there have been two similar murders near Whitechapel in a few days, Sherlock Holmes' sharp deductive is immediately stimulated to start its merciless method of elimination after observation of every apparently meaningless detail. He guesses right the victims must be street whores, and doesn't need long to work his way trough a pawn shop, an aristocratic family's stately home, a hospital and of course the potential suspects and (even unknowing) witnesses who are the cast of the gradually unraveled story of the murderer and his motive.
Sherlock Holmes and Dr. Watson embark on a search for Cleopatra's ancient necklace, which has been stolen.
In a mansion full of secret rooms and passageways, people are dying shortly after seeing the ghost of a woman in gray, as an old legend dictates. Called in to solve the mystery, Sherlock Holmes has doubts about the supernatural aspect of the crimes and focuses on a more earthly culprit.
In the midst of World War II, Sherlock Holmes rescues the Swiss inventor of a new bomb-sight from the Gestapo and brings him to England, where he quickly falls into the clutches of the evil Professor Moriarty.
Having once again avoided criminal conviction, Professor Moriarity develops a murderous plan to “finish off” his last major nemesis, Sherlock Holmes, by making him fail to prevent the perfect crime. Does it involve a family curse, the crown jewels of England, or something else…