The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
Gallant Cisco "kidnaps" murder suspect Ellen from the authorities, then sets about to prove her innocence, all with the cooperation of a sympathetic sheriff.
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
Uprooted from their comfortable home in Pennsylvania, James and Kate Tanner, along with their sons, Virgil and Andy, journey to the wild country of 1890s Wyoming to become farmers. Soon, they come face-to-face with tornadoes, bears and wolves. But through the hardships their love for each other endures, even when a local rancher sees the newcomers as "squatters" on his land, and will stop at nothing – including murder – to drive them out.
To investigate a gold-shipping scam, a postal inspector goes undercover and tries to infiltrate the gang he believes is responsible.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.
Crooked ranch foreman Thatcher sends his two henchmen, Parnell and Clint, out to murder his boss, wealthy Peter Arnold who has just arrived to retire on his ranch, bringing in tow his daughter, tomboy Jessie, who despises western life and can't wait to run off back to San Francisco. Stagecoach line owner Dave Collins and his sidekick Chito show up just in time to deter the attackers. Collins isn't done yet, though, as a gold shipment sent on one of his stages is stolen by Parnell and Clint, one of whom is recognized by Jessie, attempting to escape back to the west coast. Collins has his hands full trying to retrieve the stolen gold, and dealing with Jessie, who's fallen head-over-heels in love with him.
A young woman arrives in the western town of Headstone and helps the locals outsmart a gang of outlaws.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
Despite trying to keep his swashbuckling to a minimum, a threat to California's pending statehood causes the adventure-loving Don Alejandro de la Vega and his wife, Elena, to take action.
Will Penny, an aging cowpoke, takes a job on a ranch which requires him to ride the line of the property looking for trespassers or, worse, squatters. He finds that his cabin in the high mountains has been appropriated by a woman whose guide to Oregon has deserted her and her son. Too ashamed to kick mother and child out just as the bitter winter of the mountains sets in, he agrees to share the cabin until the spring thaw. But it isn't just the snow that slowly thaws; the lonely man and woman soon forget their mutual hostility and start developing a deep love for one another.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
Ellen has the contract for the South West Stage Line through the panhandle. Her father had the run for years and Haney, who runs the office, worked for him. But Ellen does not know that Haney is in league with Elkins and they want the stage line so they can rob the gold shipments. All they need do is stop the stage and end her contract, but that is not easy with Dave driving for Ellen.
Dave Saunders and his sidekick Chito, cowhands looking for work, arrive in Sundown Valley, Wyoming just in time to stop sheep ranch foreman Jess Rawlins from lynching cattleman Tug Caldwell. Rawlins seems set on starting a range war; but why? Before Dave and Chito can find out, they must convince Chris Marvin, Rawlins's attractive boss, that he's no good...and get out from under a framed murder charge. - Rod Crawford
In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.
Marshall "Big Jim" Cole turns in his badge and heads to Wyoming with his family in order to settle on some land left him by a relative. He faces opposition both from a neighbor who wants that land for his own sons, and from a grizzly bear nicknamed "Satan" who keeps killing Cole's livestock.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Jim Sanders (Don 'Red' Barry), young cowboy, returns to his hometown for a reunion with his boyhood friend Clay Blackburn (George Offerman Jr.). Once there he learns that Clay's father, Frank Blackburn (Ivan Miller), is the unscrupulous proprietor of a stagecoach line and is out to bankrupt the line run by Joel Hunter (Griff Barnett' ), the father of Jim's sweetheart Ruth Hunter (Betty Moran). Jim is forced to lead the fight against his best friend.
When a fed-up businessman tires of watching gold shipments disappear without a trace, he calls in the Trail Blazers (Ken Maynard, Hoot Gibson and Bob Steele) -- a legendary trio of law enforcers -- to find the gold and figure out who's behind the thefts.