To investigate a gold-shipping scam, a postal inspector goes undercover and tries to infiltrate the gang he believes is responsible.
Vignettes weaving together the stories of six individuals in the old West at the end of the Civil War. Following the tales of a sharp-shooting songster, a wannabe bank robber, two weary traveling performers, a lone gold prospector, a woman traveling the West to an uncertain future, and a motley crew of strangers undertaking a carriage ride.
A group of outlaws posing as Southern sympathizers and led secretly by freight-line owner Jim Maroon are raiding stagecoaches, and this is a threat to the Union communications. Grif Holbrook, a trouble-shooter for the Butterfield Stage Line, and Union man Barney Broderick team up to try and put a stop to the activity, when they aren't fighting over the charms of Kate Crocker.
An Arizona frontiersman steals an Indian agent's girlfriend, followed by trouble.
Ellen has the contract for the South West Stage Line through the panhandle. Her father had the run for years and Haney, who runs the office, worked for him. But Ellen does not know that Haney is in league with Elkins and they want the stage line so they can rob the gold shipments. All they need do is stop the stage and end her contract, but that is not easy with Dave driving for Ellen.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
The sheriff of a small town in southwest Texas must keep custody of a murderer whose brother, a powerful rancher, is trying to help him escape. After a friend is killed trying to muster support for him, he and his deputies must find a way to hold out against the rancher's hired guns until the marshal arrives. In the meantime, matters are complicated by the presence of a young gunslinger - and a mysterious beauty who just came in on the last stagecoach.
Outlaws attempting to kidnap Steve Blaine from a stagecoach are ran off by the sharpshooting of his sister, Sally and rescuers Jimmy Wakely and Cannonball Taylor. Steve is investigating his father's sudden death after charges of theft from the Sloan/Carson mine. Sloan is killed after Wakely learns that ore is being smuggled across the Mexican border into the mine, and then sold at the higher U.S. prices
Mary Robbins is a moderately educated, beautiful, young woman who owns the saloon called "The Poker". She is the only woman in the town of Couldee - making her the fancy of all the men there, especially to Sheriff Jack Rance. On the way to Monterey to sing at a mass officiated by Father Sienna, her stagecoach is held up by the infamous masked bandit, Ramerez. He too takes a fancy to Mary, and decides to secretly follow her, taking on the identity of an officer named, Lieutenant Johnson. While in Monterey, he dances, sings and courts Mary, who has now fallen in love with him. He then has to make a quick getaway. In the mean-time, Sheriff Jack has set up a trap to catch Ramerez at "The Poker". When Ramerez does arrive he soon discovers that Mary is the owner, and quickly changes to the identity of Lieutenant Johnson. How long can this charade last?
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
During the California Gold Rush, two down-on-their-luck vaudevillians attempt to become wealthy by bringing a girlie show to an all-male western mining town.
Stage line owner Brent has his men robbing Halliday stages and when his manager Waring learns of it, Brent has him killed. Jeff Waring arrives and takes his uncle's job. He soon learns what's happening and the Durango Kid goes into action. This keeps Halliday going and gives them a chance to get the mail contract by winning the stagecoach race.
John Russell, disdained by his "respectable" fellow stagecoach passengers because he was raised by Indians, becomes their only hope for survival when they are set upon by outlaws.
A gang of bandits takes control of Tucson in preparation for the arrival of a consignment of gold, with only a band of voluntary soldiers trying to outwit them and save the town.
Fuzzy's niece is killed in a stagecoach hold-up. Billy and Fuzzy quickly learn that the culprit, who not only killed all the passengers but also absconded with $40,000, may be holed up in lawless Pecos City.
Crooked ranch foreman Thatcher sends his two henchmen, Parnell and Clint, out to murder his boss, wealthy Peter Arnold who has just arrived to retire on his ranch, bringing in tow his daughter, tomboy Jessie, who despises western life and can't wait to run off back to San Francisco. Stagecoach line owner Dave Collins and his sidekick Chito show up just in time to deter the attackers. Collins isn't done yet, though, as a gold shipment sent on one of his stages is stolen by Parnell and Clint, one of whom is recognized by Jessie, attempting to escape back to the west coast. Collins has his hands full trying to retrieve the stolen gold, and dealing with Jessie, who's fallen head-over-heels in love with him.
A young woman arrives in the western town of Headstone and helps the locals outsmart a gang of outlaws.
The coming of the railroad to Cedar City spells the end of the stagecoach as the government gives the mail contract to the fastest means of delivery. McCord loses the stagecoach line gambling with the new buyer, but has enough hidden money to buy a ranch and some cattle. To make more money, he starts a gang to rob the railroad, express offices and steal cattle. But the railroads send out special agent Cameron to end his reign of violence.