The music-happy Bosko and Honey take a car ride, but bad luck briefly interrupts their fun.
Bosko is a construction worker who impresses Honey by making music from everything in sight, including a decapitated mouse, a typewriter and a goat filled with hot air.
After failing to crush the bird with a boulder all by himself, Wile E. Coyote (Eternicus-failurus) attempts to catch Road Runner (Speedius-ludicrous) by using an ACME Clone-O-Matic.
Wile E. Coyote decides to use a freeze ray in order to catch Road Runner.
Wile E. Coyote (Starvingus loserus) uses a falcon disguise to catch Road Runner (Speed breaking recordus).
Wile E. Coyote, on his usual hunting rounds, spies Road Runner having a drink from a water fountain during his morning sprint.
Among the strategies that fail in Wile E. Coyote's attempts to catch the Roadrunner: glue on the road, a giant rubber band, an outboard motor in a wash tub, and dressing in drag as a female Roadrunner.
Late at night, the mice come out and sing and play to the title tune, among others. That is, until the cat arrives, but he's quickly sent packing.
A streetcar conductor, Foxy has adventures with a would-be passenger hippo, a cow blocking the tracks, and a runaway train while Foxy, his passengers, and some hobos sing the title song.
Bosko and his porcine friend are hobos in a runaway boxcar.
A cartoonist draws Bosko, who promptly comes to life.
Bosko is a Mountie in the cold, snowy north. His sergeant demands that he get his man: a peg-legged villain wanted dead or alive.
Honey is trying to teach the violin to Wilbur, the one who hates music. Honey calls Bosko over. Bosko and Honey sing, dance, and play music while Wilbur continues to express its disdain.
Bosko, Honey, and Bruno spend a day at the beach.
While ice-skating on a frozen pond, Bosko and his dog discover a baby abandoned in the snow.
Bosko and Honey go on a picnic that ends badly.
Bosko and Honey yodel happily in the Alps until a series of disasters end with Honey rushing downriver on an ice floe.
Foxy the Cop is trying to enforce the law in town, but dangerous drivers and strangers who also kidnap Roxy are making this difficult.
Bosko is a soda jerk, who gives poor service to a mouse and to his former schoolteacher. Later, he must contend with Honey's bratty Wilbur.
Piggy and Fluffy have adventures on a riverboat and Uncle Tom is chased by skeletons promising to take him to Hallelujah Land.