Story follows a stagecoach ride through Old West Apache territory. On board are a cavalry man's pregnant wife, a prostitute with a broken heart, a Marshal taking in his prisoner Johnny Ringo, a crooked gambler, and the infamous Doc Holliday
Jim Bannon and his partner own a stagecoach line. With the coming of the telegraph and the end of the Pony Express, two men plot to take over and get the new mail contract. When Jim's partner is murdered and Jim's name is written in the sand beside the body, Jim is arrested. At his trial Whip brings surprising evidence that clears Jim and the two plotters are soon arrested.
In the late 19th Century, Mary Breydon, a widow, and Peggy Breydon, her daughter manage a stagecoach stop on The Cherokee Trail. The story is told from the perspective of Peggy, looking back on her adventures.
The Trail Blazers are bringing in a prisoner to stand trial for bank robbery, when several attempts are made to kill him; convinced of the man's innocence, they arrange a trap for the real thieves.
The Lone Rider Tom assumes a former outlaw's identity (Keno) to learn where the gold from his last big heist is hidden. He tries to get the info from Blackie Dawson, but Blackie gets suspicious.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.
Gunning for revenge, outlaw Nat Love saddles up with his gang to take down enemy Rufus Buck, a ruthless crime boss who just got sprung from prison.
On the eve of retirement, Captain Nathan Brittles takes out a last patrol to stop an impending massive Indian attack. Encumbered by women who must be evacuated, Brittles finds his mission imperiled.
After Cacopoulos manages to save himself from being hung on a false charge, he robs Cat Stevens and Hutch Bessy of a lot of money and steals their horses. This results in a merry chase and Stevens and Bessy become unwilling allies in Cacopoulus' revenge against the people who deserted him and framed him to get their money back.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
A small-town sheriff in the American West enlists the help of a disabled man, a drunk, and a young gunfighter in his efforts to hold in jail the brother of the local bad guy.
Expert conman Joe Thanks teams up with half-breed Bill and naive Lucy to steal $300,000 from the Indian-hating Major Cabot. Their elaborate plan is full of disguises, double-crosses, and chases, but Joe always seems to know what he's doing.
Firehand and his Apache friend Winnetou are determined to get justice for the murder of four young braves. They set off to track down the gang responsible for the horrendous act.
Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.
Bounty hunters seek shelter from a raging blizzard and get caught up in a plot of betrayal and deception.
Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
Tom Cameron must prove himself innocent after he is wrongfully charged with the murder of a prison guard.