In the late 19th Century, Mary Breydon, a widow, and Peggy Breydon, her daughter manage a stagecoach stop on The Cherokee Trail. The story is told from the perspective of Peggy, looking back on her adventures.
Singing cowboy Eddie Dean and his sidekick Soapy (Roscoe Ates) enter into the thick of things when they thwart a stagecoach holdup. Our heroes take it upon themselves to champion the cause of stage-line owner Margie Rodgers (Helen Mowery), who's being victimized by an unknown villain. Dean suspects that there's more to the case than mere robbery, and he's right: someone wants to gain control of Margie's business, and that someone is?
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Jim Bannon and his partner own a stagecoach line. With the coming of the telegraph and the end of the Pony Express, two men plot to take over and get the new mail contract. When Jim's partner is murdered and Jim's name is written in the sand beside the body, Jim is arrested. At his trial Whip brings surprising evidence that clears Jim and the two plotters are soon arrested.
Bounty hunters seek shelter from a raging blizzard and get caught up in a plot of betrayal and deception.
After the train station clerk is assaulted and left bound and gagged, then the departing train and its passengers robbed, a posse goes in hot pursuit of the fleeing bandits.
A dying Jack makes Bob and Flash promise not to tell his sister that he was an outlaw. When Bob confronts Flash with his muffler found at the stage holdup, Flash tells Mary that Bob killed her brother. Believing he can now marry Mary, he plans one more robbery. But the jealous Tiana overhears and runs for the Sheriff.
Legendary lawman Pat Garrett wins the Fourth of July buckboard race in a small Nevada town against the unscrupulous Fred Smith and pretty Lavinia White. Lavinia blames Garrett for sending her father Ivory White to jail for robbing 100,000 dollars. White, who has stashed the loot away someplace, is about to be released and plans to return the money to the express office for the sake of his children, Lavinia and Chad. Nasty Jim Judd forces Lavinia to help him rob the coach carrying Ivory and the money, counting on the fact that White will keep quiet for his daughter's sake.
After Cacopoulos manages to save himself from being hung on a false charge, he robs Cat Stevens and Hutch Bessy of a lot of money and steals their horses. This results in a merry chase and Stevens and Bessy become unwilling allies in Cacopoulus' revenge against the people who deserted him and framed him to get their money back.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
Lin McAdam rides into town on the trail of Dutch Henry Brown, only to find himself in a shooting competition against him. McAdam wins the prize, a one-in-a-thousand Winchester rifle, but Dutch steals it and leaves town. McAdam follows, intent on settling his old quarrel, while the rifle keeps changing hands and touching a number of lives.
A US marshal goes undercover to bust up a bunch of rustlers.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
Lean, mean Texas Ranger Jack Benteen locks horns with a former friend, Cash Bailey, now a ruthless drug kingpin. Though they're on opposite sides of the law, they share a love interest in the sensual Sarita. When a crew of rogue soldiers descends upon the border town for an off-the-books mission, all roads lead to a bloody, to-the-death showdown, as loyalties shift and the lines between good and evil are blurred.
The Trail Blazers are bringing in a prisoner to stand trial for bank robbery, when several attempts are made to kill him; convinced of the man's innocence, they arrange a trap for the real thieves.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
A cowboy who was trying to return the loot from a robbery finds hmself suspected of the crime.