An aging group of outlaws look for one last big score as the "traditional" American West is disappearing around them.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
Lash and Fuzzy sent to help John Watson with his stage line arrive to find him murdered. Recognizing the outlaws they trail them to their leader Baxter. But before Baxter can tell who the big boss is he is shot. After getting the stage through to assure the mail contract, Lash now realizes who the boss is.
The coming of the railroad to Cedar City spells the end of the stagecoach as the government gives the mail contract to the fastest means of delivery. McCord loses the stagecoach line gambling with the new buyer, but has enough hidden money to buy a ranch and some cattle. To make more money, he starts a gang to rob the railroad, express offices and steal cattle. But the railroads send out special agent Cameron to end his reign of violence.
Lin McAdam rides into town on the trail of Dutch Henry Brown, only to find himself in a shooting competition against him. McAdam wins the prize, a one-in-a-thousand Winchester rifle, but Dutch steals it and leaves town. McAdam follows, intent on settling his old quarrel, while the rifle keeps changing hands and touching a number of lives.
Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.
The notorious Dalton Boys have decided to go straight and move to Argentina. Just before they leave, they learn of a friend whose land is about to be seized by a greedy land company. Before they can help, the man is killed by a company assassin. The brothers do manage to rescue his widow and head for the hills. There, they decide to revert back to outlaw life. Meanwhile, a newspaper publisher's daughter falls for one of the brothers.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
A Texas Ranger and a ruthless narcotics kingpin - they were childhood friends, now they are adversaries...
A cowboy who was trying to return the loot from a robbery finds hmself suspected of the crime.
At the beginning of the 1913 Mexican Revolution, greedy bandit Juan Miranda and idealist John H. Mallory, an Irish Republican Army explosives expert on the lam from the British, fall in with a band of revolutionaries plotting to strike a national bank. When it turns out that the government has been using the bank as a hiding place for illegally detained political prisoners -- who are freed by the blast -- Miranda becomes a revolutionary hero against his will.
An ex-convict (Bob Steele) returns to his ranch; he and his sidekick (Sid Saylor) prove he was framed.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
After the train station clerk is assaulted and left bound and gagged, then the departing train and its passengers robbed, a posse goes in hot pursuit of the fleeing bandits.
Bounty hunters seek shelter from a raging blizzard and get caught up in a plot of betrayal and deception.
After Cacopoulos manages to save himself from being hung on a false charge, he robs Cat Stevens and Hutch Bessy of a lot of money and steals their horses. This results in a merry chase and Stevens and Bessy become unwilling allies in Cacopoulus' revenge against the people who deserted him and framed him to get their money back.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
Chasing jewel thieves, Captain Carson and Magpie head for the border where Carson, posing as a Chinaman, opens a store that buys jewelry. To flush the thieves into the open, Carson wins all their money at poker. They agree to sell him the jewels but plan to kill him and keep both the jewels and the money.
Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.