The sheriff of a small town in southwest Texas must keep custody of a murderer whose brother, a powerful rancher, is trying to help him escape. After a friend is killed trying to muster support for him, he and his deputies must find a way to hold out against the rancher's hired guns until the marshal arrives. In the meantime, matters are complicated by the presence of a young gunslinger - and a mysterious beauty who just came in on the last stagecoach.
At the beginning of the 1913 Mexican Revolution, greedy bandit Juan Miranda and idealist John H. Mallory, an Irish Republican Army explosives expert on the lam from the British, fall in with a band of revolutionaries plotting to strike a national bank. When it turns out that the government has been using the bank as a hiding place for illegally detained political prisoners -- who are freed by the blast -- Miranda becomes a revolutionary hero against his will.
Outlaws attempting to kidnap Steve Blaine from a stagecoach are ran off by the sharpshooting of his sister, Sally and rescuers Jimmy Wakely and Cannonball Taylor. Steve is investigating his father's sudden death after charges of theft from the Sloan/Carson mine. Sloan is killed after Wakely learns that ore is being smuggled across the Mexican border into the mine, and then sold at the higher U.S. prices
An aging group of outlaws look for one last big score as the "traditional" American West is disappearing around them.
An Arizona frontiersman steals an Indian agent's girlfriend, followed by trouble.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
A group of outlaws posing as Southern sympathizers and led secretly by freight-line owner Jim Maroon are raiding stagecoaches, and this is a threat to the Union communications. Grif Holbrook, a trouble-shooter for the Butterfield Stage Line, and Union man Barney Broderick team up to try and put a stop to the activity, when they aren't fighting over the charms of Kate Crocker.
Ellen has the contract for the South West Stage Line through the panhandle. Her father had the run for years and Haney, who runs the office, worked for him. But Ellen does not know that Haney is in league with Elkins and they want the stage line so they can rob the gold shipments. All they need do is stop the stage and end her contract, but that is not easy with Dave driving for Ellen.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Crooked ranch foreman Thatcher sends his two henchmen, Parnell and Clint, out to murder his boss, wealthy Peter Arnold who has just arrived to retire on his ranch, bringing in tow his daughter, tomboy Jessie, who despises western life and can't wait to run off back to San Francisco. Stagecoach line owner Dave Collins and his sidekick Chito show up just in time to deter the attackers. Collins isn't done yet, though, as a gold shipment sent on one of his stages is stolen by Parnell and Clint, one of whom is recognized by Jessie, attempting to escape back to the west coast. Collins has his hands full trying to retrieve the stolen gold, and dealing with Jessie, who's fallen head-over-heels in love with him.
Lin McAdam rides into town on the trail of Dutch Henry Brown, only to find himself in a shooting competition against him. McAdam wins the prize, a one-in-a-thousand Winchester rifle, but Dutch steals it and leaves town. McAdam follows, intent on settling his old quarrel, while the rifle keeps changing hands and touching a number of lives.
Fuzzy's niece is killed in a stagecoach hold-up. Billy and Fuzzy quickly learn that the culprit, who not only killed all the passengers but also absconded with $40,000, may be holed up in lawless Pecos City.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
A young woman arrives in the western town of Headstone and helps the locals outsmart a gang of outlaws.
After Cacopoulos manages to save himself from being hung on a false charge, he robs Cat Stevens and Hutch Bessy of a lot of money and steals their horses. This results in a merry chase and Stevens and Bessy become unwilling allies in Cacopoulus' revenge against the people who deserted him and framed him to get their money back.
To investigate a gold-shipping scam, a postal inspector goes undercover and tries to infiltrate the gang he believes is responsible.
The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.
An ex-convict (Bob Steele) returns to his ranch; he and his sidekick (Sid Saylor) prove he was framed.
Two men are accused of killing their boss. They are saved from the hangman's noose when two other guys are arrested, but Holt feels as though justice is still not being served. On their own, they set about to track down the genuine killer.