Medicine for Melancholy

Adam and Steve are two gay youths who have a one-night stand that ends embarrassingly. Nearly two decades later, Adam, now a Manhattan tour guide, and Steve, a psychiatrist, meet again -- but neither remembers the other from years before. The two begin dating, even playing matchmaker for their friends Michael and Rhonda, but their promising relationship hits a major snag when Adam and Steve finally recall their past connection.

Cooper is an actor who sees life as one big party, while Ed is in advertising and takes life too seriously. When Ed gets stressed over a deadline he has to meet, his brother Cooper works hard in trying to get his brother hooked up with a girl, thus a long weekend of stress and beautiful women, culminating in Ed meeting, and making love to, the woman of his dreams.

A one night stand on the rocks with a twist.

When actress Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend Brian suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful receptionist Rachel Jansen, Peter is shocked to see not only Aldous in Hawaii, but also Sarah.

When a young accountant is devastated after discovering his inspiringly beautiful girlfriend is cheating on him, his best friend, who's engaged to a girl he doesn't love, convinces him to go on a "run" and sleep with as many women as he can to get over his heart break.

An ambitious reporter probes the reasons behind the sudden split of a 1950s comedy team.

A married man's one-night stand comes back to haunt him when that lover begins to stalk him and his family.

New York City is full of lonely hearts seeking the right match, and what Alice, Robin, Lucy, Meg, Tom and David all have in common is the need to learn how to be single in a world filled with ever-evolving definitions of love.

Cursed since childhood, dentist Charlie Logan cannot find the right woman. Even worse, he learns that each of his ex-girlfriends finds true love with the man she meets after her relationship with him ends. Hearing of Charlie's reputation as a good-luck charm, women from all over line up for a quick tryst. But when Charlie meets the woman of his dreams, he must find a way to break the curse or risk losing her to the next man she meets.

College buddies chip in and promise that the group's last unmarried man will collect a cash pot. Seven years later, the kitty is worth $500,000 -- money Michael needs to pay a gambling debt. Problem is, the only other single guy is a hopeless womanizer!

Tom and Hannah have been platonic friends for 10 years. He's a serial dater, while she wants marriage but hasn't found Mr. Right. Just as Tom is starting to think that he is relationship material after all, Hannah gets engaged. When she asks Tom to be her 'maid' of honor, he reluctantly agrees just so he can attempt to stop the wedding and woo her.

Lovestruck Dustin is dating Alexis, his ideal girlfriend, but when she dumps him for coming on too strong, Dustin takes drastic measures to win her back. He asks his best friend Tank to take her on the worst rebound date imaginable - his side job - so that she will come running back to him, and Tank reluctantly agrees. However, Alexis is more than a match for Tank's shock tactics and he begins to really fall for her, leaving him torn between loyalty to Dustin and his growing attraction toward Alexis.

In Los Angeles, Max Carlyle makes a good living directing commercials and has a happy home life with his wife, Mimi, and two children. When Carlyle travels to New York City to visit his friend Charlie, who has been diagnosed with AIDS, he has repeat run-ins with a beautiful woman, Karen, and eventually sleeps with her. Though he goes home the next day and doesn't return until a year later, Carlyle's infidelity still lingers.

When Paula leaves her mate Pedro, he misses her and looks for comfort with his best friends, Javier and Sonia. Paula is having an affair with Javier. Pedro tries to find who is the secret lover of Paula, and hires a private eye. Meanwhile, while comforting Pedro, Sonia has a one night stand with him and Javier thinks she is cheating on him with her lesbian friend Luzia.

A beautiful twenty-something subsequently strikes up an essential conversation with Jack, a happily married, middle-aged and very successful businessman who is seated at another table, having just finished up a business dinner. The pair thereafter stumble into an intense one-night stand that turns into something more complicated and destructive than either of them could have expected.

Mikaela has undergone gender reassignment and is now a woman. One night at a bar, she meets a guy and takes him back to her place.

Rainbow press reporter Ludo is sentenced to 8 months, but is released on probation. But he has to work 300 hours for a local daycare center and meets Anna who has unfinished business with him.

Gabriel is a young, aspiring musical composer whose life seems stuck in the First Act. When his new musical number gets a critical reception, a theatre colleague, Perry, tells Gabriel that he needs to get a life before he can write about one – so he heads straight for his local gay bar.

An immature, newly unemployed comic must navigate the murky waters of adulthood after her fling with a graduate student results in an unplanned pregnancy.

A loving couple Martin and Lea have some problems with each other too.