Lash and Fuzzy sent to help John Watson with his stage line arrive to find him murdered. Recognizing the outlaws they trail them to their leader Baxter. But before Baxter can tell who the big boss is he is shot. After getting the stage through to assure the mail contract, Lash now realizes who the boss is.
The coming of the railroad to Cedar City spells the end of the stagecoach as the government gives the mail contract to the fastest means of delivery. McCord loses the stagecoach line gambling with the new buyer, but has enough hidden money to buy a ranch and some cattle. To make more money, he starts a gang to rob the railroad, express offices and steal cattle. But the railroads send out special agent Cameron to end his reign of violence.
Bandit Cheyenne Harry reforms because of the faith placed in him by Molly Young and her father. Soon, however, Harry is lured from the straight and narrow when he meets his old friend Ben Kent and consents to participate in Kent's plan of robbing a stagecoach.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
After her stagecoach is ambushed, a woman is tasked with holding a dangerous outlaw captive and must survive the day when the bandit’s gang tries to free him.
In order to obtain a stage coach mail contract, a new road must be built. A gang of outlaws try to prevent the building of the road.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
A young woman arrives in the western town of Headstone and helps the locals outsmart a gang of outlaws.
During the California Gold Rush, two down-on-their-luck vaudevillians attempt to become wealthy by bringing a girlie show to an all-male western mining town.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.
A gang of bandits takes control of Tucson in preparation for the arrival of a consignment of gold, with only a band of voluntary soldiers trying to outwit them and save the town.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
A small-town sheriff in the American West enlists the help of a disabled man, a drunk, and a young gunfighter in his efforts to hold in jail the brother of the local bad guy.
In 1865, a troop of Confederate soldiers led by Major Matt Stewart attack the wagon of gold escorted by Union cavalry and the soldiers are killed. The only wounded survivor tells that the war ended one month ago, and the group decides to take the gold and meet their liaison that knew that the war ended but did not inform the troop. The harsh Rolph Bainter kills the greedy man and the soldiers flee in his wagon driven by Major Stewart. When they meet a posse chasing them, Stewart gives wrong information to misguide the group; however, they have an accident with the wagon and lose the horses. They decide to stop a stagecoach and force the driver to transport them, but the posse returns and they are trapped in the station with the passenger. They realize that the men are not deputies and have no intention to bring them to justice but take the stolen gold.
Story follows a stagecoach ride through Old West Apache territory. On board are a cavalry man's pregnant wife, a prostitute with a broken heart, a Marshal taking in his prisoner Johnny Ringo, a crooked gambler, and the infamous Doc Holliday
Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.