The sheriff of a small town in southwest Texas must keep custody of a murderer whose brother, a powerful rancher, is trying to help him escape. After a friend is killed trying to muster support for him, he and his deputies must find a way to hold out against the rancher's hired guns until the marshal arrives. In the meantime, matters are complicated by the presence of a young gunslinger - and a mysterious beauty who just came in on the last stagecoach.
Outlaws attempting to kidnap Steve Blaine from a stagecoach are ran off by the sharpshooting of his sister, Sally and rescuers Jimmy Wakely and Cannonball Taylor. Steve is investigating his father's sudden death after charges of theft from the Sloan/Carson mine. Sloan is killed after Wakely learns that ore is being smuggled across the Mexican border into the mine, and then sold at the higher U.S. prices
Wild Bill Hickok, Buffalo Bill and Calamity Jane help a Texas rancher against the railroad.
An Arizona frontiersman steals an Indian agent's girlfriend, followed by trouble.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
A group of outlaws posing as Southern sympathizers and led secretly by freight-line owner Jim Maroon are raiding stagecoaches, and this is a threat to the Union communications. Grif Holbrook, a trouble-shooter for the Butterfield Stage Line, and Union man Barney Broderick team up to try and put a stop to the activity, when they aren't fighting over the charms of Kate Crocker.
Ellen has the contract for the South West Stage Line through the panhandle. Her father had the run for years and Haney, who runs the office, worked for him. But Ellen does not know that Haney is in league with Elkins and they want the stage line so they can rob the gold shipments. All they need do is stop the stage and end her contract, but that is not easy with Dave driving for Ellen.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Crooked ranch foreman Thatcher sends his two henchmen, Parnell and Clint, out to murder his boss, wealthy Peter Arnold who has just arrived to retire on his ranch, bringing in tow his daughter, tomboy Jessie, who despises western life and can't wait to run off back to San Francisco. Stagecoach line owner Dave Collins and his sidekick Chito show up just in time to deter the attackers. Collins isn't done yet, though, as a gold shipment sent on one of his stages is stolen by Parnell and Clint, one of whom is recognized by Jessie, attempting to escape back to the west coast. Collins has his hands full trying to retrieve the stolen gold, and dealing with Jessie, who's fallen head-over-heels in love with him.
Fuzzy's niece is killed in a stagecoach hold-up. Billy and Fuzzy quickly learn that the culprit, who not only killed all the passengers but also absconded with $40,000, may be holed up in lawless Pecos City.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
A young woman arrives in the western town of Headstone and helps the locals outsmart a gang of outlaws.
An old Chinese man rides into the town of Abalone, Arizona and changes it forever, as the citizens see themselves reflected in the mirror of Lao's mysterious circus of mythical beasts.
To investigate a gold-shipping scam, a postal inspector goes undercover and tries to infiltrate the gang he believes is responsible.
The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
Whip is surveying land for a railroad but a land baron and one of his daughters stands in the way.
Just before the Civil War (but after the South has seceded), Southern saboteurs try to prevent railroad construction from crossing Kansas to the frontier; army captain Nelson is sent out to oppose them. As the tracks push westward, Nelson must contend with increasingly violent sabotage, while trying to romance the foreman's pretty daughter Barbara.
Banker Mason is after the ranchers land so he can resell it to the railroad for a profit. He has the railroad agent killed and replaces him with his stooge who then offers even less than Mason. But Rocky eventually suspects Mason and when Bill Anderson informs him the agent is a fake, they head out after Mason
Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.
In order to obtain a stage coach mail contract, a new road must be built. A gang of outlaws try to prevent the building of the road.