Not having heard that war has erupted between the U.S. and Mexico, a wagon train heads west, only to find itself threatened by the Mexicans who have teamed up with hostile Indians.
Four unwitting heroes cross paths on their journey to the sleepy town of Silverado. Little do they know the town where their family and friends reside has been taken over by a corrupt sheriff and a murderous posse. It's up to the sharp-shooting foursome to save the day, but first they have to break each other out of jail, and learn who their real friends are.
Jim Harvey is hired to guard a small wagon train as it makes its way west. The train is attacked by Indians and Harvey, hoping to persuade Aguila, the chief, to call off the attack due to Harvey's having saved his son's life, leaves the train to negotiate. He is captured and the rest of the train is wiped out except for two sisters. Escaping and showing up in town later, Harvey is nearly hanged as a deserter, but gets away. Eventually caught by the sheriff and his posse, they are attacked by Indians. This time the Indians are defeated and Aguila, captured and dying, reveals the identity of the white man who engineered the initial attack on the wagon train, just as the perpetrator rides up behind them.
A western bandit is reformed by his love for a little girl.
Sent by the Army, Andy Thomas poses as a renegade to find out who has been harassing the wagon trains.
A wagon train heads for Denver with a cargo of whisky for the miners. Chaos ensues as the Temperance League, the US cavalry, the miners and the local Indians all try to take control of the valuable cargo.
Nineteen year old pioneer woman Marty has recently married. She goes west with her husband Clem, hoping to start a new life. But Clem unexpectedly dies, and Marty finds herself alone, two months pregnant. Widower Clark offers her a marriage of convenience: she needs food and money, and he needs someone to take care of his daughter Missie. She accepts his proposal as a temporary solution.
Buck Roberts is leading a wagon train of railroad supplies and Jim Corkle and his henchman Loder are out to stop them by using white men dressed as Indians for the attacks.
When a handful of settlers survive an Apache attack on their wagon train they must put their lives into the hands of Comanche Todd, a white man who has lived with the Comanches most of his life and is wanted for the murder of three men.
In 1846, a reporter for the New York Herald joins a wagon train bound for the Oregon Territory. He hopes to confirm a rumor that President Polk is sending in soldiers disguised as settlers in order to strengthen American claims to the Territory.
Jubal Troop is a cowboy who is found in a weakened condition, without a horse. He is given shelter at Shep Horgan's large ranch, where he quickly makes an enemy in foreman Pinky, a cattleman who accuses Jubal of carrying the smell of sheep.
Rancher Rex Allen receives a summons from his uncle. an old time frontiersman, that he is in trouble. The uncle has been hired to lead a modern-day band of adventurers on a wagon train retracing the route taken by their ancestors 100 years ago. Before Rex can talk to his uncle, the uncle is murdered, and Rex sets out to find the killer and the motive by taking his uncle's place as the leader of the wagon train.
Bill, who is about to lead a wagon train to California, has a map to a valuable gold field and Rocky is after the map. When Rocky and his men attack, Ken Manning breaks it up and later identifies Rocky and his men as the attackers. Expelled from the wagon train, they stampede a buffalo herd puting the Indians on the warpath. After the Indians attack the wagon train, Rocky thinks he can get the map.
Young scout Breck Coleman leads a wagon train along the dangerous trail to Oregon as he tries to get the affection of the beautiful pioneer Ruth Cameron and plans his revenge on the harsh scoundrels who murdered a friend of his in the past.
Two men with questionable pasts, Glyn McLyntock and his friend Cole, lead a wagon-train load of homesteaders from Missouri to the Oregon territory...
Cattle baron John Chisum joins forces with Billy the Kid and Pat Garrett to fight the Lincoln County Land War in the New Mexico Territory of 1878.
A scout leading a wagon train through hostile Indian country gets involved with a Sioux chief's daughter.
A young man seeks vengeance on the outlaws who killed his father.
When three Texas Rangers try to investigate kidnapped Mexicans being used as forced labor in the mines of Silver Bullet, they are framed for murder by the town's corrupt sheriff.
When he runs for sheriff, Hoppy is beaten by Jerry Doyle, the gutless wonder voted for by every crook in town. When Hoppy moves to have the new sheriff impeached, outlaw leader Tad Hammond hires forty gunslingers to stop him. Stop Hoppy? Hah!