On her b-day, settler's daughter Apanatschi receives her father's secret gold mine but greedy neighboring prospectors resort to murder and kidnapping in order to get the gold, forcing the girl and her brother to seek Winnetou's protection.
To restore his family's lost wealth, a young Boston lad stows away on a ship bound for the California Gold Rush. When their very proper butler gives chase, all roads lead to nonstop adventure, wild and woolly characters, and a lucky punch that leads to a bonanza of belly laughs!
When a fed-up businessman tires of watching gold shipments disappear without a trace, he calls in the Trail Blazers (Ken Maynard, Hoot Gibson and Bob Steele) -- a legendary trio of law enforcers -- to find the gold and figure out who's behind the thefts.
Hank Davis kills Jack Lewis to get his gold mine. Bruce Conway brings him in but then realizes Davis is the only one that knows where the mine is. Bruce and his pal Whitey rescue Davis from the lynch mob only to have Davis' gang catch them and leave them in the desert to die.
Rodeo champ Gene Autry inherits half interest in both a ranch and a mine that provides steady employment for the surrounding rancheros. Unfortunately, the other half goes to Easterner Barbara Erwin (Carol Hughes), who is only interested in monetary remuneration. To convince Gene to buy her share, Barbara enters into an unholy alliance with unscrupulous attorneys Arnold (Ivan Miller) and Fry (Sam Flint), who, without their client's consent, hire a gang of thugs headed by Tommick (John Merton). When a ranchero (Elias Gamboa) is mortally wounded in the ensuing gun battle, Barbara sees the error of her way and switches sides.
Two jobless Americans convince a prospector to travel to the mountains of Mexico with them in search of gold. But the hostile wilderness, local bandits, and greed all get in the way of their journey.
Two men, Thurman and Beady, and a woman, Georgia, ply a confidence game in Alaska by selling 'salted' gold mines to gullible newcomers. But the cold Far North gets too hot for them and they move to greener pastures in the western United States. Business is good until a young cattleman, Tom Hatfield, falls for their trap. But Georgia falls in love with him and this causes problems for her partners.
When three Texas Rangers try to investigate kidnapped Mexicans being used as forced labor in the mines of Silver Bullet, they are framed for murder by the town's corrupt sheriff.
Stephen Westcott and Ed Martin scheme to put Jane Travers' wagon line out of business. They want to use it take over all the wagon- train traffic going west. Hoppy, California and Lucky must make sure that doesn't happen.
When he runs for sheriff, Hoppy is beaten by Jerry Doyle, the gutless wonder voted for by every crook in town. When Hoppy moves to have the new sheriff impeached, outlaw leader Tad Hammond hires forty gunslingers to stop him. Stop Hoppy? Hah!
Hoppy and Lucky have been called in to investigate a series of stage holdups. The robbers are taking gold from Colby's mine and Hoppy suspects it may be ex-outlaw Colby himself. When Speedy strikes gold, Hoppy borrows it and announces a gold shipment hoping to catch the gang and their leader.
Finishing a trail drive, Hoppy and the boys head to town and immediately get caught up in the conflict between school teacher Miss Abott and next door saloon owner Mawson. When Miss Abott disappears, Hoppy gets a clue to her location and rescues her from Mawson's cabin. It looks like Mawson is the man he wants, but Hoppy finds an item that indicates otherwise.
Sue Morgan gets Hoppy and his friends to join their expedition looking for Indian artifacts. Expedition leader Atwood makes a deal with nearby cattle rustler Morgan to loot the Indian treasures instead and sell them. Hoppy is on to their plan and pretending to leave follows them. Not only is he outnumbered by Morgan's men, but California has himself about to be sacrificed in an Indian ritual.
Before he was killed by Mark Foster's men, Bud Lawton willed part ownership in his ranch to Hoppy and his two pals. When the three arrive they find a fake posing as Lawton. When they expose the imposter, Foster gets the Sheriff to jail them for Lawton's murder.
Joe Weller has instigated a conflict over water rights between two ranchers. The idea is to have the ranchers do each other in then move in and take over. Hoppy and the good guys won't let this happen.
As rustled cattle have mysteriously disappeared, Johnny sends for his friend Hoppy, Hoppy arrives and immediately suspects Dan Slack. Realizing his telegram about Slack was intercepted, he locks up the operator Lafe knowing he can escape. Tailing Lafe he finds a secret entrance to a mine and inside finds the missing cattle. But Slack's men also find him just as the cattle are stampeded through the mine shaft.
Hoppy is busy chasing stagecoach bandits who sing as they rob.
Lee Garvin has eloped with the daughter of a railroad man who didn't approve of the marriage. Hoppy steps in when the young man is framed for murder.
European bad guy Baron Bendor leads some local townsmen in a plot to obtain horses through theft. Hoppy and his sidekicks Lucky and Speedy must find and expose the horse thieves.
Hopalong Cassidy and Johnny Nelson ride to the mountains to help a man and his daughter save their logging business from someone who is sabotaging their efforts.