While Holmes is away recuperating, Watson is left to help a damsel in distress.
Holmes and Dr. Watson take on the case of a beautiful woman whose husband has vanished. The investigation proves strange indeed, involving six missing midgets, villainous monks, a Scottish castle, the Loch Ness monster, and covert naval experiments.
Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".
When Watson reads from the newspaper there have been two similar murders near Whitechapel in a few days, Sherlock Holmes' sharp deductive is immediately stimulated to start its merciless method of elimination after observation of every apparently meaningless detail. He guesses right the victims must be street whores, and doesn't need long to work his way trough a pawn shop, an aristocratic family's stately home, a hospital and of course the potential suspects and (even unknowing) witnesses who are the cast of the gradually unraveled story of the murderer and his motive.
Holmes, retired to Sussex, is drawn into a last case when his arch enemy Moriarty arranges with an American gang to kill one John Douglas, a country gentleman with a mysterious past. Holmes' methods baffle Watson and Lestrade, but his results astonish them. In a long flashback, the victim's wife tells the story of the sinister Vermissa Valley.
After her sister dies under mysterious circumstances, a young heiress seeks Holmes' help when she feels threatened by her brutish stepfather.
After the King of Rovenia has been assassinated, Holmes and Watson are engaged to escort his son to Europe via Algiers, aboard a transatlantic ocean liner which also carries a number of suspicious persons, any of whom may be involved in a plot to also assassinate him.
During WWII several murders occur at a convalescent home where Dr. Watson has volunteered his services. He summons Holmes for help and the master detective proceeds to solve the crime from a long list of suspects including the owners of the home, the staff and the patients recovering there.
In a city rotting from within, a cursed coin promising untold riches leaves only disappearances in its wake. When Elle, son of powerful politician Mr. Vichai, vanishes, two broken men—Time, a disgraced cop, and Marvin, a fallen lawyer—are hired to find the truth. One million baht is on the line. But some truths come at a higher price.
Sherlock Holmes and Watson are on the trail of a criminal and scientific mastermind who seems to control monsters and creations which defy belief.
Holmes goes on the trail of a Rembrandt painting, stolen by a drug-addicted artist.
In London, a secret society led by lawyer Thaddeus Merrydew collects the assets of any of its deceased members and divides them among the remaining members. Society members start dropping like flies. Sherlock Holmes is approached by member James Murphy's widow, who is miffed at being left penniless by her husband. When Captain Pyke is shot, Holmes keys in on his mysterious Chinese widow as well as the shady Merrydew. Other members keep dying: Malcom Dearing first, then Mr. Baker. There is also an attempt on the life of young Eileen Forrester, who became a reluctant society member upon the death of her father. Holmes' uncanny observations and insights are put to the test.
After the death of his wife, wealthy retiree Justin Playfair creates a fantasy world for himself in which he is the legendary detective Sherlock Holmes, even dressing like the character. Out of concern for Justin's money more than his health, his brother Blevins puts him under the care of psychiatrist Dr. Mildred Watson. As Dr. Watson grows fond of Justin, she begins to play along with his theories, eventually becoming an assistant in his investigations.
After spending decades living in the shadow of his more famous and successful sibling, Consulting Detective Sigerson Holmes (Wilder) is called upon to help solve a crucial case that leads him on a hilarious trail of false identities, stolen documents, secret codes... and exposed backsides.
When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.
England, at the start of World War Two. Mysterious wireless broadcasts, apparently from Nazi Germany are heard over the BBC. They warn of acts of terror in England, just before they take place. Baffled, the Defense Committee call in Sherlock Holmes.
A young woman turns to Holmes for protection when she's menaced by an escaped killer seeking missing treasure. However, when the woman is kidnapped, Holmes and Watson must penetrate the city's criminal underworld to find her.
Concerned about his friend's cocaine use, Dr. Watson tricks Sherlock Holmes into travelling to Vienna, where Holmes enters the care of Sigmund Freud. Freud attempts to solve the mysteries of Holmes' subconscious, while Holmes devotes himself to solving a mystery involving the kidnapping of Lola Deveraux.
The sensational details of a gruesome murder in The Daily Gazette have London in a panic, as a blood-thirsty madman - more vicious than Jack the Ripper - preys upon the city. Of greater concern to Scotland Yard, however, is that the account of the murder was published nearly two hours prior to the crime having been committed! Sherlock Holmes and Dr. Watson - the Great Detective and his faithful assistant and chronicler - find themselves challenged with one of their most baffling cases - "The Case of the Woman Who Was Murdered Tomorrow"! Will an innocent man be sent to the gallows? How much blood will be shed before a scarred fiend is brought to justice? ...And who are the mysterious Shadow Watchers, a coven of ominous figures who orchestrate terror from within the darkness? Starring Anthony D.P. Mann as Holmes and Terry Wade as Dr. Watson, "Sherlock Holmes and the Shadow Watchers" is a horrifying new adventure, produced with the kind permission of the Conan Doyle Estate*.
The corpse of a shabbily dressed young woman has been discovered in the mud flats of the Thames at low tide. Police assume she's a prostitute, but Dr. Watson suspects something more and goes to his old friend Holmes, now retired and at very loose ends.