Jim Crosby, the product of a broken home, becomes a gangster and goes to prison. Meanwhile, Ann Payton, an heiress, converts a saloon into a mission. She is engaged to her father's secretary, Temple Vaughn, a gambler. Jim is released from prison and seeks shelter at the mission. Temple becomes indebted to gambler Phil Johnson and is forced to arrange a crooked poker game involving some of his wealthy friends. Jim overhears the plot and, realizing that Temple is Ann's fiancé, robs the poker game and puts a check Temple forged into Temple's own pocket.
Bessie Allen, a girl of the slums, dances in the streets of the Lower East Side of New York to the delight of the crowds. She becomes an orphan when her father, in a drunken stupor, kills her mother, and then himself. Bessie is knocked down by the car of Mrs. Latham, a society matron, who takes an interest in the girl and procures her a job as a dress model.
George Bell, a wild young man, lives with his rancher father, Thomas Bell, in Paradise Valley, California. When George sells his father's favorite horse, Mr. Bell turns him out, and George becomes a grain salesman in St. Louis. Meanwhile, Polly Martin lives with her father Bill, an ex-businessman who has sunk to day-labor because of his addiction to alcohol. Bill frequently abuses Polly, and when he falls to his death from a high girder, Polly becomes a nurse in the Salvation Army in St. Louis. George falls in love with Polly after he saves her from the advances of a drunk, but she will not marry him because of his wild past.
In 1869, enemies of railroad magnate Richard Strong attempt to ruin him. Richard thwarts them, largely through the help of Charles Dalton, but then Charles tries to seduce Elinor, Richard's wife. Although she rebuffs Charles, Richard accuses her of infidelity, so Elinor leaves him and goes to Paris. Richard follows her, but, caught in the middle of the 1870 riots, he cannot get near her. Charles, also in Paris, finally convinces Richard that nothing had come of his interest in Elinor, but Richard now believes that Elinor no longer loves him.
When penniless Westie Phillips briefly meets wealthy Martha Gorham, he falls in love, but Martha forgets the encounter. Harry Arnold, courting Martha, invites her out sailing and arranges to have the yacht wrecked near an uncharted island so that he can be alone with her until rescuers arrive. Meanwhile, without knowing Martha is on board, Westie secures a position on the yacht.
Although Kenneth Carmont and Esther Saunders, criminal Bert Saunders' sister, love each other, Esther marries detective Elwood Collins, who agrees to stop pursuing Bert if she accepts his proposal. One night, Kenneth and Esther hide Bert, who has escaped from the police. The same night, Kenneth's father is murdered. The evidence implicates Kenneth, who cannot supply his whereabouts at the time of the crime, as that would give away Bert. Esther cannot clear Kenneth for the same reason, and because it would let her husband know that she was with her former sweetheart.
After watching her mother die gradually from a broken heart, Roberta, an illegitimate child, decides to seek vengeance from her father Bradley, who ran away before she was born. Bradley is wealthy now, and so Roberta secures a job as his secretary and schemes to ruin his financial empire.
Finding himself penniless, Lawrence Ashmore, whose late father was ruined on the stock exchange, obtains a position as a reporter. Ashmore is assigned to investigate the reported fatal illness of Jesse Craven, one of Wall Street's financial monarchs.
Helder is a happy family man, but one day his wife receives a letter from her brother Albert, who managed to escape from prison.
Karl Sterner falls for Jenny, a beautiful young woman from an impoverished background, and soon discovers that he cannot control her willful personality - which proves to cause many conflicts in their marriage.
A father-and-son team of cons gamble their firm’s assets. The son is caught investing money that doesn't belong to him and is indicted on a swindling charge. The plot gets spicy when the District Attorney handling the case is his former sweetheart's husband. This situation gives the DA an opportunity to prosecute his romantic rival.
For Nita Valyez, who is half-Spanish and half-Irish, Carlos represents potential violence and danger, two things to which she is both attracted and repelled. In contrast, she has only a passing interest in Big Jim, the town's honest, good-hearted sheriff. Then, after Carlos kills a faro dealer, he forces Nita to make an escape with him.
Hartley, fascinated by the vampish Leonie, steals and serves a term in prison. Not satisfied with this downfall, Leonie again works her womanly charms upon Dr. Gerald, who is engaged to Johanna, the adopted daughter of Dr. McLean. Learning of the woman's designs on the young doctor, Hartley denounces her in Gerald's presence. In response, Gerald foolishly renounces Johanna and his friendship with Dr. McLean. However, when Leonie discovers that Johanna is her own daughter whom she had deserted as a child, she becomes conscience-stricken, gives up the young man and begs forgiveness.
Priscilla Worth, an innocent country girl, goes to the city to visit her aunt, who has sent for her, thinking that her childlike simplicity will afford a welcome relief to Vincent Morgan, a wealthy bachelor and man-about-town. The plan works, but soon after Vincent and Priscilla's marriage, Vincent, besieged by his friends to return to his gay life and suspicious of his wife's relationship with Durant--an artist who has painted her portrait--yields to temptation.
Indore, an Indian woman married to the English Captain Terence Unger is imprisoned by the prince after she gives birth to a baby daughter named Agatha. On his deathbed, Unger beseeches his friend Francis Duane to care for Agatha which Duane does, returning to England with the infant.
Marion Clark, a manicurist, is unimpressed by the wealthy but dissipated men who frequent her shop, preferring city editor Dick Strong, who lives in her boardinghouse. Dick's sister Gladys, however, is intrigued by the wilder side of life in New York and allows one of the boarders to take her to a lively party.
Japanese poet Akira living in Tokyo, loves American Ruth Vale, who was placed in the care of Akira's father when her missionary parents died. Ruth returns Akira's affections until she meets Edward, but the American proves an unfaithful husband. Three years later, Ruth is gravely ill while Edward amuses himself with his new lover, Adrienne Chester, but Akira comforts the dying woman with the promise that he will protect her little daughter Blossom.
Marianna Miller, who together with her sister Sarah pounds the pavements, looking for a job. After a period of starvation and deprivation Marianna is hired as secretary to duplicitous businessman Philip Hancock.
Captain of the Yale football team, Paul Potter becomes engaged to his small-town Indiana sweetheart Sylvia Castle but once in the big city he becomes involved with married society girl Muriel Evers and finds Sylvia too provincial, ending their engagement. In time Sylvia meets alcoholic actor, Henry Leamington, who encourages her to become an actress while she helps him get sober. In New York she finds success and becomes reacquainted with Paul for whom she still has feelings, but comes to realize he is a lout and returns to Henry.
Lisza Tapenko (Bara) is governess in the household of Prince Arbasoff (Charles Clary). After the death of his wife, Lisza and he become involved, but because of the difference in social station he refuses to marry her. Lisza's former lover, Vassya (Richard Ordynski), convinces her to join the revolution and she goes off to the group headquarters in Switzerland. But the prince's little boy begs to have Lisza come back, so he goes after her and marries her.