A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
A small-town sheriff in the American West enlists the help of a disabled man, a drunk, and a young gunfighter in his efforts to hold in jail the brother of the local bad guy.
Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.
A stage headed West with a group of passengers is attacked by Cheyenne Indians, and takes refuge in a nearby ghost town.
English gunsmith Jonathon Tibbs travels to the American West in the 1880s to sell firearms to the locals. He inadvertently acquires a reputation of quickness on the draw due to his wrist mounted Derringer style weapon. Soon gaining the post of sheriff, he endeavours to clean up the town using what skills he has—and by multilateral diplomacy.
In the late 19th Century, Mary Breydon, a widow, and Peggy Breydon, her daughter manage a stagecoach stop on The Cherokee Trail. The story is told from the perspective of Peggy, looking back on her adventures.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
Bounty hunters seek shelter from a raging blizzard and get caught up in a plot of betrayal and deception.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
A group of unlikely travelling companions find themselves on the same stagecoach to Cheyenne. They include a drunken doctor, a bar girl who's been thrown out of town, a professional gambler, a travelling liquor salesman, a banker who has decided to embezzle money, a gun-slinger out for revenge and a young woman going to join her army captain husband. All have secrets but when they are set upon by an Indian war party and then a family of outlaws, they find they must all work together if they are to stay alive.
A peace-loving man named Ben Kane takes a job as deputy marshal of Lords, in the old West. Kane is no lawman, but he accepts the badge because he has an old score to settle with the town's chief trouble-maker. Once on the job, Kane must also deal with a young sharpshooter named Billy Young and a sharp and sassy saloon dancer, Lily.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
After escaping from jail, outlaw Wes McQueen is convinced by his old partner in crime to do one last heist.
Bandit Pistol Pete enters a lawless western town and robs a bank. The town is in desperate need of a sheriff. Enter wandering cowboy Goofy who notices a pretty girl being held up in a stagecoach robbery by Pete. Lovestruck and completely oblivious to Pete, he foils the robbery while getting to know the girl better. This earns him a reputation as a great gunslinger and he is challenged to apprehend Pete. Pete tries to get his revenge on Goofy but every attempt backfires due to Goofy's clumsiness usually directed unintentionally at Pete.
Trouble in Colorado is tying up Union troops needed back east during the Civil War and Lieut. Burke is sent to investigate. Macklin and his gang are causing the problems and Capt. Mason joins them. When Burke catches up with them he also finds Mason, his brother.
Lambert has the stagecoach wrecked killing the Commissioner so his phony replacement can alter Coonskin's land survey. When Red Ryder exposes the survey hoax, Lambert has his stooge Sheriff put Red in jail.
Stagecoach robbers take the money Hoppy was going to use to buy cattle so Hoppy, California and Lin go after them.
Hoppy is busy chasing stagecoach bandits who sing as they rob.