Wilson and his saddle pal Andy Clyde come to the rescue of a group of ranchers who are being victimized by villain Ace Larabee (Douglas Kennedy). Ace has inside information that the railroad is coming through the territory, and he intends to grab up all the land and sell it to the train execs for a tidy profit.
Story follows a stagecoach ride through Old West Apache territory. On board are a cavalry man's pregnant wife, a prostitute with a broken heart, a Marshal taking in his prisoner Johnny Ringo, a crooked gambler, and the infamous Doc Holliday
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
Fuzzy purchases a saloon with a large sack of gold from the mine he owns with his partner Billy. When a crooked lawyer uses underhanded methods to try taking over the saloon, Billy works to bring the lawyer and his no-good gang to justice.
U.S. Marshals "Nevada Jack" McKenzie and "Sandy" Hopkins, working undercover, investigate a plot to rob a widow and her daughter of a mine which they know to be filled with gold-laden ore, but the widow believes it has played out. A hermit, hanging around the mine and killing, impartially, anyone who enters the mine, impedes the investigation somewhat.
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
In the late 19th Century, Mary Breydon, a widow, and Peggy Breydon, her daughter manage a stagecoach stop on The Cherokee Trail. The story is told from the perspective of Peggy, looking back on her adventures.
Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.
The Trail Blazers are bringing in a prisoner to stand trial for bank robbery, when several attempts are made to kill him; convinced of the man's innocence, they arrange a trap for the real thieves.
Jim Bannon and his partner own a stagecoach line. With the coming of the telegraph and the end of the Pony Express, two men plot to take over and get the new mail contract. When Jim's partner is murdered and Jim's name is written in the sand beside the body, Jim is arrested. At his trial Whip brings surprising evidence that clears Jim and the two plotters are soon arrested.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.
A mysterious preacher protects a humble prospector village from a greedy mining company trying to encroach on their land.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Three lawmen hunt down thieves who are robbing a tungsten mine.
Bounty hunters seek shelter from a raging blizzard and get caught up in a plot of betrayal and deception.
A stagecoach is plagued by robberies, but it takes an undercover Wells Fargo agent to discover that a rival company is responsible.
Bolton's men blow up the wagon carrying the mine payroll and Marshal Crash Corrigan is supposedly killed in the explosion. A man finds his badge and gives it to Bolton. Thinking Crash dead, Bolton gives the badge away and it ends up with the Sheriff. Crash is OK and the Range Busters know Bolton is the head of the gang but that he gets his orders from someone else and that is the man they want.
A landowner tries to drink his neighbor's molybdenum milkshake and winds up having him killed. It's up to Allan Lane to find out what happened and apprehend the culprits.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.