The music-happy Bosko and Honey take a car ride, but bad luck briefly interrupts their fun.
Bosko is a construction worker who impresses Honey by making music from everything in sight, including a decapitated mouse, a typewriter and a goat filled with hot air.
After failing to crush the bird with a boulder all by himself, Wile E. Coyote (Eternicus-failurus) attempts to catch Road Runner (Speedius-ludicrous) by using an ACME Clone-O-Matic.
Wile E. Coyote decides to use a freeze ray in order to catch Road Runner.
Wile E. Coyote (Fallious-flatius) uses an ACME Weather Control Kit to try and catch Road Runner (Speedius-gonzalicus) through various weather-related tricks.
Among the strategies that fail in Wile E. Coyote's attempts to catch the Roadrunner: glue on the road, a giant rubber band, an outboard motor in a wash tub, and dressing in drag as a female Roadrunner.
Late at night, the mice come out and sing and play to the title tune, among others. That is, until the cat arrives, but he's quickly sent packing.
After Acme products fail him one too many times in his dogged pursuit of the Roadrunner, Wile E. Coyote decides to hire a billboard lawyer to sue the Acme Corporation.
A streetcar conductor, Foxy has adventures with a would-be passenger hippo, a cow blocking the tracks, and a runaway train while Foxy, his passengers, and some hobos sing the title song.
Bosko, Honey, and Bruno spend a day at the beach.
Ride Him, Bosko! is a western-flavored cartoon with lots of shooting gags involving body reduction, and card characters singing! There's also an alcohol gag that has a really strong one turning a male piano player into a woman instantly!
While ice-skating on a frozen pond, Bosko and his dog discover a baby abandoned in the snow.
Bosko is a Mountie in the cold, snowy north. His sergeant demands that he get his man: a peg-legged villain wanted dead or alive.
The old toymaker goes to sleep, and his toys immediately come to life and sing "Red-Headed Baby." A red-haired baby doll begins the song. She's soon joined by her sweetheart, a toy soldier named Napoleon. A spider briefly spoils the fun when he descends upon the toys and grabs the doll. It's up to Napoleon to save her.
Piggy and Fluffy have adventures on a riverboat and Uncle Tom is chased by skeletons promising to take him to Hallelujah Land.
During the Great War, Bosko and a fearsome beast are in a dogfight. Bosko loses, but that's only the first battle.
Things are hopping at a certain Mexican cafe and then Foxy walks in and the customers go really wild.
A bee returns home late after a night out having too much honey. His wife leaves him, but quickly ends up in the clutches of an evil large predator.
It is Christmas in the Snake Bite Desert, and Road Runner is off on his usual sprint once again.
Bosko is a brave little boxer who battles the champion, Gas House Harry. The enormous brute proves a bit much, even for a plucky underdog. Some of the animation is later reused in "Bosko's Parlor Pranks" by M.G.M. in 1934.