After failing to crush the bird with a boulder all by himself, Wile E. Coyote (Eternicus-failurus) attempts to catch Road Runner (Speedius-ludicrous) by using an ACME Clone-O-Matic.
The music-happy Bosko and Honey take a car ride, but bad luck briefly interrupts their fun.
Bosko is a construction worker who impresses Honey by making music from everything in sight, including a decapitated mouse, a typewriter and a goat filled with hot air.
Wile E. Coyote, on his usual hunting rounds, spies Road Runner having a drink from a water fountain during his morning sprint.
It is Christmas in the Snake Bite Desert, and Road Runner is off on his usual sprint once again.
Wile E. Coyote (Fallious-flatius) uses an ACME Weather Control Kit to try and catch Road Runner (Speedius-gonzalicus) through various weather-related tricks.
Late at night, the mice come out and sing and play to the title tune, among others. That is, until the cat arrives, but he's quickly sent packing.
Among the strategies that fail in Wile E. Coyote's attempts to catch the Roadrunner: glue on the road, a giant rubber band, an outboard motor in a wash tub, and dressing in drag as a female Roadrunner.
A streetcar conductor, Foxy has adventures with a would-be passenger hippo, a cow blocking the tracks, and a runaway train while Foxy, his passengers, and some hobos sing the title song.
A cartoonist draws Bosko, who promptly comes to life.
Two courting hillbilly dogs, which is Goopy Geer and his girlfriend, go to the big barn dance. Then a villian comes over to try to shoot him with a gun, then fights, and the villian got on fire and escaped thanks to the walking stove.
Bosko and Bruno escape from a speeding train via a handcar; make a failed attempt to steal a chicken; and end up on a runaway boxcar.
A mannequin in the city dump improvises a working piano from junk, then plays and sings the title song. Various discarded items join in with song or dance.
Bosko whistles "It Ain't Gonna Rain No Mo" as he walks down the sidewalk in the pouring rain. His umbrella provides a good sailboat when he wants to cross a flooded street. Meanwhile, Honey is getting dressed and made up. She's about to remove her nightgown when she realizes that we in the audience are watching her. She goes behind a modesty screen, but the mirror reveals all to us. Bosko arrives at Honey's place and one of her friends opens the door. Little does she know that several of her friends are downstairs waiting to surprise her. This is Honey's birthday. Honey's little yapping dog causes trouble before and during the party. Worse trouble comes from her pupil--a little kitten who hides underneath a flowerpot and can't get out from under it. When he finally does, he causes a minor catastrophe.
A circus parade, to the title tune. Next, a series of sideshow acts: the wild boy, the rubber man, siamese twin pigs, a tattooed man, a hula-dancing hippo, an Indian snake (or goat) charmer. Into the ring, we have a hippo riding a horse (much to the horse's dismay), a high-wire act (again, to the title song), and finally a lion tamer.
The last Goopy Geer cartoon. The king returns to his castle, and asks where the queen is; she's in the parlor, and won't be seen, according to the title song. He goes to his throne and summons his jester, Goopy Geer. A black knight arrives and threatens one of the young ladies in court; Goopy Geer fights him off, first with an ax, then in armor from kitchen utensils, then butting him with a mounted animal head, which makes the knight's armor fall apart. He pulls it together again and runs away.
Goopy, a dog of no particular personality, but a crackerjack piano player, plays several songs on the stage of a nightclub. We spend a fair amount of time watching the patrons and staff of the nightclub.
Bosko and Honey go to the zoo. Honey is frightened by the lion, but Bosko is the one who ends up in danger.
Bosko and his friends are cutting down trees in a forest. He battles a burly woodsman named Pierre who has gone off and kidnapped his beloved Honey.
Ride Him, Bosko! is a western-flavored cartoon with lots of shooting gags involving body reduction, and card characters singing! There's also an alcohol gag that has a really strong one turning a male piano player into a woman instantly!