Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.
A wagon train heads for Denver with a cargo of whisky for the miners. Chaos ensues as the Temperance League, the US cavalry, the miners and the local Indians all try to take control of the valuable cargo.
After the Civil War, ex-Union Colonel John Henry Thomas and ex-Confederate Colonel James Langdon are leading two disparate groups of people through strife-torn Mexico. John Henry and company are bringing horses to the unpopular Mexican government for $35 a head while Langdon is leading a contingent of displaced southerners, who are looking for a new life in Mexico after losing their property to carpetbaggers. The two men are eventually forced to mend their differences in order to fight off both bandits and revolutionaries, as they try to lead their friends and kin to safety.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
After a massacre of an Indian village by the U.S army, a survivor, Yellow shirt (Ray Danton) goes after them for revenge. His journey becomes a deadly adventure. His life will be threatened by the hostility of the desert, snakes, hallucinations and of course his encounter with his enemies…
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Bounty hunters seek shelter from a raging blizzard and get caught up in a plot of betrayal and deception.
A Union Cavalry outfit is sent behind confederate lines in strength to destroy a rail supply center. Along with them is sent a doctor who causes instant antipathy between him and the commander. The secret plan for the mission is overheard by a southern belle who must be taken along to assure her silence.
On the eve of retirement, Captain Nathan Brittles takes out a last patrol to stop an impending massive Indian attack. Encumbered by women who must be evacuated, Brittles finds his mission imperiled.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.
Curley Smith, a lieutenant of the Texas Rangers, gets chased by a band of smugglers after getting caught spying on them and becomes injured. Anita, the daughter of the chief smuggler tends to him and the two of them fall in love. Dean, a member of the renegade, becomes jealous of their romance, and will do whatever he can to get rid of Curley - fair or foul.
It is 1879 in the Dakota Territories, a band of men who set out to find and recover a family of settlers that has mysteriously vanished from their home. Expecting the offenders to be a band of fierce natives, but they soon discover that the real enemy stalks them from below.
The Trail Blazers are bringing in a prisoner to stand trial for bank robbery, when several attempts are made to kill him; convinced of the man's innocence, they arrange a trap for the real thieves.
Cardelanche, the son of an Indian chief, returns from the East to find himself rejected by his own people. He is made captain of the U.S. army when he saves a detachment of cavalry from a group of renegade Indians, and further removes himself from his race when he develops a relationship with Miriam, the daughter of the Fort Remmington commandant. Lieutenant Parkman (Walker) gets into a fight with Cardelanche when Parkman is demoted, while General Custer's troops are slaughtered by Cardelanche's people. Cardelanche decides that his true allegiance is to his own race, and gives up Miriam to return to them.
A stage headed West with a group of passengers is attacked by Cheyenne Indians, and takes refuge in a nearby ghost town.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
As a Civil War veteran spends years searching for a young niece captured by Indians, his motivation becomes increasingly questionable.
Two jobless Americans convince a prospector to travel to the mountains of Mexico with them in search of gold. But the hostile wilderness, local bandits, and greed all get in the way of their journey.
Jim Bannon and his partner own a stagecoach line. With the coming of the telegraph and the end of the Pony Express, two men plot to take over and get the new mail contract. When Jim's partner is murdered and Jim's name is written in the sand beside the body, Jim is arrested. At his trial Whip brings surprising evidence that clears Jim and the two plotters are soon arrested.