When Jerry rustles cheese from the Dry Gulch General Store, Sheriff Mutt Dillin hires Tom, the fastest trap in the West.
On a snowy night in the city, Jerry is comfortably asleep in his hole inside a penthouse, while Tom tries to keep from freezing to death in the alley below.
Tom, famous baritone Signor Thomasino Catti-Cazzaza, enthralls a concert audience with his rendition of "Largo al factotum", from Rossini's "Il Barbiere di Siviglia", while Jerry strives for sleep under the stage.
Tom enjoys the role of top cat until an adorable red-and-white-haired kitten is brought into the house of a young blonde woman.
Jack's mother throws Jack's magic beans outside under Sylvester Cat's sleeping box, and the cat is whisked to the world above, where he finds a huge Tweety Bird in the castle of the legendary Giant.
Exhausted traveler Porky Pig drives into a town looking for a hotel. He is delighted to find one with a 10 cents per-night fee. Unfortunately, its manager is Daffy Duck.
Sylvester's carnivorous pursuit of Tweety Bird continues, winding up the cat's spirit in Hell, where he meets a satanic bulldog.
Sylvester Cat accepts a position as mouse-catcher on a ship, and his son, Junior, accompanies him. They encounter baby kangaroo Hippety Hopper being shipped from Australia and, as usual, mistake Hippety for a giant mouse.
A drunken stork delivers a baby mouse to the home of Mr. and Mrs. Sylvester Cat. Sylvester is about to eat the little rodent when it calls him Daddy. Touched, Sylvester adopts the mouse as his son - which, distressingly, attracts every hungry cat in the neighborhood to his door!
Sniffles the mouse's non-stop talking foils both the burglar and a tipsy Officer Bear, who's trying to sneak past his rolling pin-toting, sleepwalking wife.
"As everyone knows," the narrator begins, "goldfish must have water... and cats hate water." And so it goes.
Sniffles the mouse, in his first appearance in a Warner Bros. cartoon, goes to a drugstore and gets drunk on a cold remedy, then befriends an electric razor and gets it drunk as well.
An alley cat attempts to steal the goldfish Andy Panda just bought from a pet shop, but the fish proves too clever for him.
Pepe Le Pew, the eternally amorous skunk, is in Paris, where his stench sends a female cat upward to hit a freshly painted flagpole, which puts a white stripe on her back and causes Pepe to think she also is a skunk. He lustfully pursues her into the Louvre art gallery.
The cat of the house has its nap interrupted by two playing puppies, which sets off a chain of events.
Mickey, Minnie, Horace Horsecollar, and Clarabelle Cow go on a musical wagon ride until Peg-Leg Pete tries to run them off the road.
Jerry's mouse hole connects two homes, with Tom living in one residence, a neighboring cat in the other. Jerry decides the best survival plan is pitting the cats against each other, without their knowledge.
Jerry keeps sleepwalking and doing things unknowingly to Tom. He becomes aware of this and tries to stay awake.
Jerry is paid a visit by a look-alike magician.
Tom chases Jerry through city streets, gets run over by a streetcar (twice), and follows Jerry into a department store. In the toy department, they have some fun with radio-controlled cars and a collection of mouse dolls. They move on to sporting goods, where Jerry manages to combine table tennis with croquet.