After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.
Spike waves to a young woman driving a red pickup truck through the desert of Needles, California every day; it is the highlight of his day. In this combined animated and live-action special, we meet an aerobics instructor, Jenny, who wants to be a big city jazz dancer. She and Spike drive around looking at the desert scenery and spending some time at a roller rink. However, when Spike is accidentally thrown out of the skating rink he runs off and is pursued by people on a nighttime coyote hunt.
Eli is a burglar who is caught in the act by Twinkle, an heiress who coerces him into a sexual relationship. Their violent break-up makes him a fugitive in search of a new identity. He lands in a trashy trailer park where he touches the lives of several dysfunctional residents.
The cat of the house has its nap interrupted by two playing puppies, which sets off a chain of events.
A series of gags at a dog show, including a stage revue. A dog gets into a trunk of roller skates and crashes through the stage show.
An alley cat attempts to steal the goldfish Andy Panda just bought from a pet shop, but the fish proves too clever for him.
Pepe Le Pew, the eternally amorous skunk, is in Paris, where his stench sends a female cat upward to hit a freshly painted flagpole, which puts a white stripe on her back and causes Pepe to think she also is a skunk. He lustfully pursues her into the Louvre art gallery.
Snoopy embarks upon his greatest mission as he and his team take to the skies to pursue their arch-nemesis, while his best pal Charlie Brown begins his own epic quest.
When Jerry rustles cheese from the Dry Gulch General Store, Sheriff Mutt Dillin hires Tom, the fastest trap in the West.
On a snowy night in the city, Jerry is comfortably asleep in his hole inside a penthouse, while Tom tries to keep from freezing to death in the alley below.
Tom, famous baritone Signor Thomasino Catti-Cazzaza, enthralls a concert audience with his rendition of "Largo al factotum", from Rossini's "Il Barbiere di Siviglia", while Jerry strives for sleep under the stage.
Waif mouse Jerry, encrusted with snow, peers through a warmly lit window at Tom asleep by the fire in a room full of cheese.
Tom enjoys the role of top cat until an adorable red-and-white-haired kitten is brought into the house of a young blonde woman.
An old woman has a cat, a dog, and a canary. The cat and dog fight even worse than normally. Fed up, she tells them both off, then threatens to throw them both out if there's any more trouble.
Sniffles the mouse's friends talk him into putting a bell around the neck of the troublesome house cat.
A dog chasing a quail keeps getting outsmarted.
Officer Pooch is called out to rescue a kitten that is repeatedly chased up telephone poles and trees by an aggressive little dog.
"As everyone knows," the narrator begins, "goldfish must have water... and cats hate water." And so it goes.
Porky can't sleep because mice demolish his plates. A cat offers help and gets the mice out, but invites some friends so Porky still can't sleep.
Exhausted traveler Porky Pig drives into a town looking for a hotel. He is delighted to find one with a 10 cents per-night fee. Unfortunately, its manager is Daffy Duck.