An aging group of outlaws look for one last big score as the "traditional" American West is disappearing around them.
Brown fights a swindler and his pal, Hatton, finds a way to help a robbery victim buy back his property.
In a cantina across the border, Bob Hamlin shoots a man that threatens his friend. He and his pals escape but return that night for the dance as Bob is attracted to Conchita. Running once more from the Rurales, Bob takes Conchita. They escape again only to find themselves pinned down when Buck and his gang of horse thieves attack.
In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.
Carl Beldon has disappeared and the Trail Blazers have been sent to investigate. Arriving in town, they find that 'Honest John' controls everything. He even prints his own money. He also has a gang and they set out to finish off the heroes.
Outlaws plan a robbery to take place during a championship prizefight in Carson City, Nevada.
Montana Rivers finally escapes her father who had forced her to wear men's clothing and help in robbing and cheating. She is taken in by friendly Indians and stays at their camp. Later, Akkomi, chief of the tribe, asks his friend Dan Overton to take the girl as it is not good for her to remain in the camp. Dan provides for "Tana" and falls in love with her but, because of her past, she keeps him at a distance. Jim Harris comes by and recognizes Tana as the boy robber, but when he attempts to blacken her past, Dan gives him a beating which paralyzes him. Jim then stays on with Dan, who regrets his hastiness. Eventually Tana's father appears and demands that Tana go away with him. She refuses but also does not tell Dan of this trouble.
Bank robber Graham Dorsey spends a few hours with beautiful widow Amanda Starbuck, in which time his gang takes part in a disastrous holdup. Learning of his comrades' demise, Dorsey goes on the lam. Believing her short-term lover was killed by the law, Amanda decides to make the most of having had a liaison with the supposedly deceased desperado by writing a book about him. Much to his confusion, the still-living Dorsey watches as his name becomes legendary.
Lash and Fuzzy sent to help John Watson with his stage line arrive to find him murdered. Recognizing the outlaws they trail them to their leader Baxter. But before Baxter can tell who the big boss is he is shot. After getting the stage through to assure the mail contract, Lash now realizes who the boss is.
After the train station clerk is assaulted and left bound and gagged, then the departing train and its passengers robbed, a posse goes in hot pursuit of the fleeing bandits.
After Cacopoulos manages to save himself from being hung on a false charge, he robs Cat Stevens and Hutch Bessy of a lot of money and steals their horses. This results in a merry chase and Stevens and Bessy become unwilling allies in Cacopoulus' revenge against the people who deserted him and framed him to get their money back.
Lin McAdam rides into town on the trail of Dutch Henry Brown, only to find himself in a shooting competition against him. McAdam wins the prize, a one-in-a-thousand Winchester rifle, but Dutch steals it and leaves town. McAdam follows, intent on settling his old quarrel, while the rifle keeps changing hands and touching a number of lives.
Lawyer Butler, wanting Jeff Carson's ranch, has the Sheriff and his gang frame the bank holdup on him. Then they kill a witness that could free Carson and blame the murder on his son Sunset. But Sunset escapes, frees his father, and then sets a trap to catch the real killers.
In order to obtain a stage coach mail contract, a new road must be built. A gang of outlaws try to prevent the building of the road.
An ex-convict (Bob Steele) returns to his ranch; he and his sidekick (Sid Saylor) prove he was framed.
Danny, a greenhorn from New York comes to the Mexican border in search for his older brother whom he has always looked up to. A Texas Ranger charged with bringing in, El Tigre and his gang of bandits, takes Danny under his wing.
James Kincaid controls the local water supply and plans to do away with the other ranchers. Government agent Sandy Saunders arrives undercover to investigate Kincaid's land swindle scheme, and win the heart of one of his victims, Fay Denton.
Chasing jewel thieves, Captain Carson and Magpie head for the border where Carson, posing as a Chinaman, opens a store that buys jewelry. To flush the thieves into the open, Carson wins all their money at poker. They agree to sell him the jewels but plan to kill him and keep both the jewels and the money.
A man who's a dead ringer for the leader of an outlaw gang kills the gang leader, then takes his place to try to bring the gang to justice.
A Treasury Department engraver is being held captive by a counterfeiting gang that wants him to make counterfeit plates for them. A lawman is sent to rescue him.