Retired wealthy sea captain Jim McKay arrives in the Old West, where he becomes embroiled in a feud between his future father-in-law, Major Terrill, and the rough and lawless Hannasseys over a valuable patch of land.
A wanted-fugitive, called "Nevada," is wounded by a pursuing posse of lawmen, and is left to die on the desert by his companion, Bill Hall. He is rescued by a young rancher, Ben Ide, who is in love with Ina Blaine, daughter of a neighboring rancher. While "Nevada" is recovering, he and Ina fall in love but, through his loyalty to Ben, he sends her away. Going home, Ina falls into the clutches of Bill Hall, now heading a gang of rustlers, but the real leader is Les Setter who is posing as an honest rancher, and he has designs on Ina himself.
The drought-plagued ranchers of Sundown have to market their cattle at a loss in order to meet mortgage payments held by banker Cylus Cuttler. Then, Sheriff Tex Rockett is forced to quarantine all the cattle on the local ranches because of a hoof-and-mouth disease outbreak. Steve Davis herds his cattle to the railhead anyway, and Tex is forced to arrest him. Urged on by the banker's son, Nick Cuttler, the angry ranchers storm the jail, but Steve's sister Bee persuades them to await the trial. Steve, with Nick's help, breaks jail and is told he must kill Tex to aid the ranchers. Meanwhile, government man Bret Stockton and Tex see Nick and his men treating cattle in an unusual way. Tex finally proves that the Cuttlers have been treating the cattle with acid to give a false impression of the hoof-and-mouth disease.
Lawyer Bowdre has started a war between the ranchers and the homesteaders planning to take over the homesteaders land when they are wiped out. Rancher Dan Stockton, having just married homesteader Gail Dawson, is caught in the middle. He suspects Bowdre is behind the war and it's not long before he gets a chance to prove it.
There's a dispute over water rights, and every lawman that arrives to settle the score is killed. It's up to Lash to settle the score and find out who is behind all the killings.
While Fuzzy is waiting for his mail order bride, McCallister frames him for murder. McCallister then advises Matilda to marry Fuzzy so she will get the money when he is hung. But Billy breaks up the wedding and goes after the real killer.
Down-and-out cowhand Jim Garry is asked by his old friend Tate Riling to help mediate a cattle dispute. When Garry arrives, however, it soon becomes clear that Riling has not been entirely forthright. Garry uncovers Riling's plot to dupe local rancher John Lufton out of a fortune. When Lufton's firecracker of a daughter, Amy, gets involved, Garry must choose between his old loyalties and what he knows to be right.
Jack Holt, Billie Dove, and Noah Beery Sr., who starred together in Wanderers of the Wasteland, appear together again. Madeline Hammond, the sister of ranchman Al Hammond, arrives from the East. Gene Stewart, a rough and rowdy cowboy, convinces Madeline to marry him while he is on a drunken spree. Madeline sets out to reform him, and he sets out to rid their little section of the West of a band of outlaws.
When three Texas Rangers try to investigate kidnapped Mexicans being used as forced labor in the mines of Silver Bullet, they are framed for murder by the town's corrupt sheriff.
Stephen Westcott and Ed Martin scheme to put Jane Travers' wagon line out of business. They want to use it take over all the wagon- train traffic going west. Hoppy, California and Lucky must make sure that doesn't happen.
When he runs for sheriff, Hoppy is beaten by Jerry Doyle, the gutless wonder voted for by every crook in town. When Hoppy moves to have the new sheriff impeached, outlaw leader Tad Hammond hires forty gunslingers to stop him. Stop Hoppy? Hah!
Hoppy and Lucky have been called in to investigate a series of stage holdups. The robbers are taking gold from Colby's mine and Hoppy suspects it may be ex-outlaw Colby himself. When Speedy strikes gold, Hoppy borrows it and announces a gold shipment hoping to catch the gang and their leader.
Hoppy, Lucky and California search for a mine owned by Trudy Pendleton after it was taken from her by thw swindling gambler Ace Gibson. They find the mine and Hoppy fights Gibson over it.
Finishing a trail drive, Hoppy and the boys head to town and immediately get caught up in the conflict between school teacher Miss Abott and next door saloon owner Mawson. When Miss Abott disappears, Hoppy gets a clue to her location and rescues her from Mawson's cabin. It looks like Mawson is the man he wants, but Hoppy finds an item that indicates otherwise.
Sue Morgan gets Hoppy and his friends to join their expedition looking for Indian artifacts. Expedition leader Atwood makes a deal with nearby cattle rustler Morgan to loot the Indian treasures instead and sell them. Hoppy is on to their plan and pretending to leave follows them. Not only is he outnumbered by Morgan's men, but California has himself about to be sacrificed in an Indian ritual.
Before he was killed by Mark Foster's men, Bud Lawton willed part ownership in his ranch to Hoppy and his two pals. When the three arrive they find a fake posing as Lawton. When they expose the imposter, Foster gets the Sheriff to jail them for Lawton's murder.
As rustled cattle have mysteriously disappeared, Johnny sends for his friend Hoppy, Hoppy arrives and immediately suspects Dan Slack. Realizing his telegram about Slack was intercepted, he locks up the operator Lafe knowing he can escape. Tailing Lafe he finds a secret entrance to a mine and inside finds the missing cattle. But Slack's men also find him just as the cattle are stampeded through the mine shaft.
Hoppy is busy chasing stagecoach bandits who sing as they rob.
Lee Garvin has eloped with the daughter of a railroad man who didn't approve of the marriage. Hoppy steps in when the young man is framed for murder.
European bad guy Baron Bendor leads some local townsmen in a plot to obtain horses through theft. Hoppy and his sidekicks Lucky and Speedy must find and expose the horse thieves.